지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Bone homeostasis is regulated by the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoporosis, rheumatoid arthritis and periodontal disease are related with up-regulated osteoclast formation and its activity. Gol-Swae-Bo(Drynariae Rhizoma) is widely used on skeletal disease. In this study, we sought to examine the effect of Drynariae Rhizoma in RANKL-induced osteoclast differentiation. The extract of Drynariae Rhizoma inhibited RANKL-induced osteoclast differentiation in a dose dependent manner without cytotoxicity. receptor activator of nuclear factor-kB ligand(RANKL) mediated IkB degradation in bone marrow macrophages(BMMs). However, the extract of Drynariae Rhizoma inhibited RANKL induced IkB degradation in BMMs. And mRNA expression of OSCAR, TRAP, c-Fos and NFATc1 was suppressed by the extract of Drynariae Rhizoma. Moreover, the extract of Drynariae Rhizoma inhibited the protein expression of NFATc1 and c-Fos induced by RANKL. After all the analysis, these results suggest that Drynariae Rhizoma may be good candidate of medicine in the treatment of bone-related disease.
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참고문헌
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Teitelbaum, S. L. / 2003 / Genetic regulation of osteoclast development and function / Nat. Rev. Genat 4 : 638 ~ 649
2. [학술지(정기간행물)] - Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
3. [학술지(정기간행물)] - Takayanagi, H. / 2007 / Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems / Nat. Rev. Immunol 7 : 292 ~ 304
4. [학술지(정기간행물)] - Lee, Z. H. / 2003 / Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts / Biophys. Res. Commun 305 : 211 ~ 214
5. [학술지(정기간행물)] - Takayanagi, H. / 2000 / Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts / Dev. Cell 23 : 889 ~ 901
2. [학술지(정기간행물)] - Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423 : 337 ~ 342
3. [학술지(정기간행물)] - Takayanagi, H. / 2007 / Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems / Nat. Rev. Immunol 7 : 292 ~ 304
4. [학술지(정기간행물)] - Lee, Z. H. / 2003 / Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts / Biophys. Res. Commun 305 : 211 ~ 214
5. [학술지(정기간행물)] - Takayanagi, H. / 2000 / Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts / Dev. Cell 23 : 889 ~ 901
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