지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Previously, we showed that Dangguisoo-san (DGSS), an herbal formula that has been traditionally used for the treatment of blood stagnation, is also applicable for inflammatory lung diseases. Activation of Nrf2, an anti-inflammatory transcription factor, and suppression of NF-κB, a pro-inflammatory transcription factor, were suggested as an underlying mechanism. However, the constituents responsible for these activities remain unidentified. To this end, we prepared the water extracts of the 9 constituents of DGSS and tested for their effect on Nrf2 by using an Nrf2-Luciferase reporter cell line and western blot analysis. Results show that Carthamus tinctorius L.(CT), one of the 9 constituents of DGSS, strongly activated Nrf2. Similarly, when measured the effect of the 9 constituents on NF-κB by using an NF-κB-Luciferase reporter cell line and western blotting for nuclear p65, indicative of activated NF-κB, most constituents were capable of suppressing NF-κB in various degrees. However, CT and Cyperus rotundus L. (CR) strongly suppressed NF-κB activity elicited by LPS. Of note, CT activated Nrf2 and suppressed NF-κB strongly as well. Our results contributes to corroborating the anti-inflammatory effects of DGSS by identifying CT and CR as two major herbs responsible for activating Nrf2 and suppressing NF-κB. These results suggest that CT and CR represent some of the effects of DGSS in the regulation of inflammation.
목차
Introduction
Materials and Methods
Discussion
References
참고문헌 (11)
참고문헌 신청
Hyun Lim / 2009 / Anti-inflammatory Activity of the Constituents of the Roots of Aralia continentalis / Archives of Pharmacal Research 32(9):1237~1243
Lyu, J. H. / 2012 / Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB / J. Ethnopharmacol 140(1):107~116
Lyu, J. H. / 2011 / ent-kaur-16-en-19-oic Acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2 / J. Ethnopharmacol 137(3):1442~1449
Yoon, S.B / 2009 / Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages / J. Ethnopharmacol 125(2):286~290
Xian, Y / 2011 / Comparison on the anti- inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice / J. Ethnopharmacol 137(3):1425~1430
Lyu, J. H. / 2012 / Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB / J. Ethnopharmacol 140(1):107~116
Lyu, J. H. / 2011 / ent-kaur-16-en-19-oic Acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2 / J. Ethnopharmacol 137(3):1442~1449
Yoon, S.B / 2009 / Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages / J. Ethnopharmacol 125(2):286~290
Xian, Y / 2011 / Comparison on the anti- inflammatory effect of Cortex Phellodendri Chinensis and Cortex Phellodendri Amurensis in 12-O-tetradecanoyl-phorbol-13-acetate-induced ear edema in mice / J. Ethnopharmacol 137(3):1425~1430
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UCI(KEPA) : I410-ECN-0101-2015-510-001220497