지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.2
- 수록면
- 36 - 41 (6page)
이용수
이 논문의 연구 히스토리 (2)
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초록· 키워드
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Skin disease is one of the most common diseases and its incidence is increasing dramatically in modern society. Specially, many attempts have been made to treat chronic skin inflammation diseases, such as psoriasis and atopic dermatitis, but effective therapies for the immune cell-mediated skin diseases, including psoriasis and atopic dermatitis have not been developed. Until recently, several drug candidates which were claimed to be effective for skin diseases have been reported, but most of them are not used to treat chronic skin disease. Especially, Psoriasis is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells and various immune-related cytokines. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators are up-regulated in psoriasis development. Contact- and mediator-dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. TMP and its derivatives themselves effectively inhibited in vitro cell migration, tube formation, and the expression of angiogenic factors. However, TMP and its derivatives induced side effects including hemolysis and local side effects. Therefore, in an attempt to reduce the toxicity and the undesirable side effects of TMP and derivatives, a liposomal formulation was prepared and tested for its effectiveness. TMP and derivatives liposomes retained the effectiveness of TMP in vitro while side effects were reduced. These results support the conclusion that TMP effectively inhibits in vitro angiogenesis, with the possibility that use as a psoriasis relief agent.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCES
참고문헌 (19)
참고문헌 신청
Folkman, J. / 1971 / Tumor angiogenesis: therapeutic implications / N. Engl. J. Med 285:1182~1186
Ossowski, L. / 1983 / Antibodies to plasminogen activator inhibit human tumor metastasis / Cell 35:611~619
Holash, J. / 1999 / New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF / Oncogene 18:5356~5362
Hood, J. D. / 2002 / Tumor regression by targeted gene delivery to the neovasculature / Science 296:2404~2407
Weidner, N. / 1993 / Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma / Am. J. Pathol 143:401~409
Ossowski, L. / 1983 / Antibodies to plasminogen activator inhibit human tumor metastasis / Cell 35:611~619
Holash, J. / 1999 / New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF / Oncogene 18:5356~5362
Hood, J. D. / 2002 / Tumor regression by targeted gene delivery to the neovasculature / Science 296:2404~2407
Weidner, N. / 1993 / Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma / Am. J. Pathol 143:401~409
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UCI(KEPA) : I410-ECN-0101-2015-400-001242905