지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.86 No.2
- 발행연도
- 2014.2
- 수록면
- 55 - 60 (6page)
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초록· 키워드
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Purpose: Current management for patients with differentiated thyroid cancer includes near total thyroidectomy and radioactive iodine therapy followed by administration of supraphysiological doses of levothyroxine (L-T4). Although hyperthyroidism is a well known risk factor for osteoporosis, the effects of L-T4 treatment on bone mineral density (BMD) in patients with thyroid cancer do not appear to be as significant as with endogenous hyperthyroidism. In this study, we evaluated the impact of long-term suppressive therapy with L-T4 on BMD and bone turn over markers in Korean female patients receiving L-T4 suppressive therapy.
Methods: We enrolled 94 female subjects (mean age, 50.84 ± 11.43 years) receiving L-T4 after total or near total thyroidectomy and radioactive iodine therapy for thyroid cancer (mean follow-up period, 12.17 ± 4.27 years). The subjects were divided into three groups by thyroid stimulating hormone (TSH) level (group 1 with TSH level ≤0.001 μIU/mL, group 2 with TSH level between 0.001 and 0.17 μIU/mL, group 3 with TSH level >0.17 μIU/mL) and four groups by quartile of free T4 level. L-T4 dosage, BMD (examined by dual-energy x-ray absorptiometry), and bone turnover markers were evaluated according to TSH and free T4 levels.
Results: No significant decrease was detected in BMD or bone turnover markers according to TSH level or free T4 level. Also, the prevalence of osteoporosis and osteopenia was not different among groups.
Conclusion: Long-term L-T4 suppressive therapy after thyroid cancer management did not affect bone density or increase the prevalence of osteoporosis even though TSH levels were supraphysiologically suppressed.
Methods: We enrolled 94 female subjects (mean age, 50.84 ± 11.43 years) receiving L-T4 after total or near total thyroidectomy and radioactive iodine therapy for thyroid cancer (mean follow-up period, 12.17 ± 4.27 years). The subjects were divided into three groups by thyroid stimulating hormone (TSH) level (group 1 with TSH level ≤0.001 μIU/mL, group 2 with TSH level between 0.001 and 0.17 μIU/mL, group 3 with TSH level >0.17 μIU/mL) and four groups by quartile of free T4 level. L-T4 dosage, BMD (examined by dual-energy x-ray absorptiometry), and bone turnover markers were evaluated according to TSH and free T4 levels.
Results: No significant decrease was detected in BMD or bone turnover markers according to TSH level or free T4 level. Also, the prevalence of osteoporosis and osteopenia was not different among groups.
Conclusion: Long-term L-T4 suppressive therapy after thyroid cancer management did not affect bone density or increase the prevalence of osteoporosis even though TSH levels were supraphysiologically suppressed.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Eriksen EF. / 1986 / Normal and pathological remodeling of human trabecular bone : three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease / Endocr Rev 7 : 379 ~ 408
2. [학술지(정기간행물)] - Mosekilde L. / 1990 / Effects of thyroid hormones on bone and mineral metabolism / Endocrinol Metab Clin North Am 19 : 35 ~ 63
3. [학술지(정기간행물)] - Diamond T. / 1991 / A therapeutic dilemma : suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma / J Clin Endocrinol Metab 72 : 1184 ~ 1188
4. [학술지(정기간행물)] - Florkowski CM. / 1993 / Bone mineral density in patients receiving suppressive doses of thyroxine for thyroid carcinoma / N Z Med J 106 : 443 ~ 444
5. [학술지(정기간행물)] - Franklyn JA. / 1992 / Long-term thyroxine treatment and bone mineral density / Lancet 340 : 9 ~ 13
2. [학술지(정기간행물)] - Mosekilde L. / 1990 / Effects of thyroid hormones on bone and mineral metabolism / Endocrinol Metab Clin North Am 19 : 35 ~ 63
3. [학술지(정기간행물)] - Diamond T. / 1991 / A therapeutic dilemma : suppressive doses of thyroxine significantly reduce bone mineral measurements in both premenopausal and postmenopausal women with thyroid carcinoma / J Clin Endocrinol Metab 72 : 1184 ~ 1188
4. [학술지(정기간행물)] - Florkowski CM. / 1993 / Bone mineral density in patients receiving suppressive doses of thyroxine for thyroid carcinoma / N Z Med J 106 : 443 ~ 444
5. [학술지(정기간행물)] - Franklyn JA. / 1992 / Long-term thyroxine treatment and bone mineral density / Lancet 340 : 9 ~ 13
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UCI(KEPA) : I410-ECN-0101-2015-510-001271641