지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.86 No.3
- 발행연도
- 2014.3
- 수록면
- 122 - 129 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: To identify the correlation of the model for end-stage liver disease (MELD) scores with the assessment of the risk of hepatic function after hemihepatectomy in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV).
Methods: A case-control study was performed based on data for 141 consecutive patients who underwent curative right hepatic resection between January 2006 and June 2010.
Results: All patients were Child-Pugh class A. The mean age of the patients was 50 years (range, 29?73 years). The group included 114 men (80.9%) and 27 women (19.1%). The distribution of MELD scores (median, 7; range, 6?14) and indocyanine green retention rate at 15 minutes (ICG-R15) (median, 9.2%; range, 1.1%?19.5%) showed no significant correlation (P = 0.615). Only one perioperative death (0.7%) occurred within 30 days, which was the result of liver failure by hepatic artery dissection during the Pringle maneuver. Hepatic dysfunction occurred in 25 patients (17.7%) after liver resection. In multivariate analysis, male gender, increased HBV DNA level, and elevated serum aspartate transaminase level were significantly related with hepatic dysfunction. Tumor size and satellite nodule were closely associated with tumor recurrence in HBV-related HCC after right hemihepatectomy and satellite nodule was a predisposing factor for mortality in those patients.
Conclusion: MELD score does not accurately predict hepatic function after right hemihepatectomy in patients with resectable HBV-related HCC. MELD scores were not correlated with the ICG-R15 values in patients with Child-Pugh class A.
Methods: A case-control study was performed based on data for 141 consecutive patients who underwent curative right hepatic resection between January 2006 and June 2010.
Results: All patients were Child-Pugh class A. The mean age of the patients was 50 years (range, 29?73 years). The group included 114 men (80.9%) and 27 women (19.1%). The distribution of MELD scores (median, 7; range, 6?14) and indocyanine green retention rate at 15 minutes (ICG-R15) (median, 9.2%; range, 1.1%?19.5%) showed no significant correlation (P = 0.615). Only one perioperative death (0.7%) occurred within 30 days, which was the result of liver failure by hepatic artery dissection during the Pringle maneuver. Hepatic dysfunction occurred in 25 patients (17.7%) after liver resection. In multivariate analysis, male gender, increased HBV DNA level, and elevated serum aspartate transaminase level were significantly related with hepatic dysfunction. Tumor size and satellite nodule were closely associated with tumor recurrence in HBV-related HCC after right hemihepatectomy and satellite nodule was a predisposing factor for mortality in those patients.
Conclusion: MELD score does not accurately predict hepatic function after right hemihepatectomy in patients with resectable HBV-related HCC. MELD scores were not correlated with the ICG-R15 values in patients with Child-Pugh class A.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Pugh RN. / 1973 / Transection of the oesophagus for bleeding oesophageal varices / Br J Surg 60 : 646 ~ 649
2. [학술지(정기간행물)] - Kamath PS. / 2001 / A model to predict survival in patients with end-stage liver disease / Hepatology 33 : 464 ~ 470
3. [학술지(정기간행물)] - Makuuchi M. / 1993 / Surgery for small liver cancers / Semin Surg Oncol 9 : 298 ~ 304
4. [학술지(정기간행물)] - Schneider PD. / 2004 / Preoperative assessment of liver function / Surg Clin North Am 84 : 355 ~ 373
5. [학술지(정기간행물)] - Edmondson HA. / 1954 / Primary carcinoma of the liver : a study of 100 cases among 48, 900 necropsies / Cancer 7 : 462 ~ 503
2. [학술지(정기간행물)] - Kamath PS. / 2001 / A model to predict survival in patients with end-stage liver disease / Hepatology 33 : 464 ~ 470
3. [학술지(정기간행물)] - Makuuchi M. / 1993 / Surgery for small liver cancers / Semin Surg Oncol 9 : 298 ~ 304
4. [학술지(정기간행물)] - Schneider PD. / 2004 / Preoperative assessment of liver function / Surg Clin North Am 84 : 355 ~ 373
5. [학술지(정기간행물)] - Edmondson HA. / 1954 / Primary carcinoma of the liver : a study of 100 cases among 48, 900 necropsies / Cancer 7 : 462 ~ 503
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2015-510-001268602