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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 34 - 39 (6page)
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초록· 키워드
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Cigarette smoke is considered a major risk factor for vascular diseases. There are many toxic compounds in cigarette smoke, including acrolein and other α,β-unsaturated aldehydes, which are regarded as mediators of inflammation and vascular dysfunction. Furthermore, recent studies have revealed that acrolein, an α,β-unsaturated aldehyde in cigarette smoke, induces inflammatory mediator expression, which is known to be related to vascular diseases. In this study, we investigated whether Korean Red Ginseng (KRG) water extract suppressed acrolein-induced cyclooxygenase (COX)-2 expression in human umbilical vein endothelial cells (HUVECs). Acrolein-induced COX-2 expression was accompanied by increased levels of phosphorylated p38 in HUVECs and KRG inhibited COX-2 expression in HUVECs. These results suggest that KRG suppresses acrolein-induced COX-2 expression via inhibition of the p38 mitogen-activated protein kinase signaling pathway. In addition, KRG exhibited an inhibitory effect on acrolein-induced apoptosis, as demonstrated by annexin Vepropidium iodide staining and terminal deoxynucleotidyl transferasemediated dUTP nick end-labeling assay. Consistent with these results, KRG may exert a vasculoprotective effect through inhibition of COX-2 expression in acrolein-stimulated human endothelial cells.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (40)
참고문헌 신청
1. [학술지(정기간행물)] - Campbell SC / 2008 / Smoking and smoking cessation e the relationship between cardiovascular disease and lipoprotein metabolism: a review / Atherosclerosis 201 : 225 ~ 235
2. [학술대회논문] - Spira A / 2004 / Effects of cigarette smoke on the human airway epithelial cell transcriptome / Proc Natl Acad Sci U S A 101 : 10143 ~ 10148
3. [학술지(정기간행물)] - Gokkusu C / 2001 / Oxidant-antioxidant profiles of platelet rich plasma in smokers / Addict Biol 6 : 325 ~ 330
4. [학술지(정기간행물)] - Ockene IS / 1997 / Cigarette smoking, cardiovascular disease, and stroke: a statement for healthcare professionals from the American Heart Association. American Heart Association Task Force on Risk Reduction / Circulation 96 : 3243 ~ 3247
5. [학술지(정기간행물)] - 이승은 / 2010 / Differentially-expressed genes related to atherosclerosis in acrolein-stimulated human umbilical vein endothelial cells / BioChip Journal 4 (4) : 264 ~ 271
2. [학술대회논문] - Spira A / 2004 / Effects of cigarette smoke on the human airway epithelial cell transcriptome / Proc Natl Acad Sci U S A 101 : 10143 ~ 10148
3. [학술지(정기간행물)] - Gokkusu C / 2001 / Oxidant-antioxidant profiles of platelet rich plasma in smokers / Addict Biol 6 : 325 ~ 330
4. [학술지(정기간행물)] - Ockene IS / 1997 / Cigarette smoking, cardiovascular disease, and stroke: a statement for healthcare professionals from the American Heart Association. American Heart Association Task Force on Risk Reduction / Circulation 96 : 3243 ~ 3247
5. [학술지(정기간행물)] - 이승은 / 2010 / Differentially-expressed genes related to atherosclerosis in acrolein-stimulated human umbilical vein endothelial cells / BioChip Journal 4 (4) : 264 ~ 271
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UCI(KEPA) : I410-ECN-0101-2015-520-001297365