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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 8 - 15 (8page)
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초록· 키워드
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Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-kB. High levels of lipid peroxide (LPO) and increased activity of myeloperoxidase (MPO), a biomarker of neutrophil infiltration, are observed in H. pylori-infected gastric mucosa. Panax ginseng Meyer, a Korean herb medicine, is widely used in Asian countries for its biological activities including anti-inflammatory efficacy. The present study aims to investigate whether Korean Red Ginseng extract (RGE) inhibits H. pylori-induced gastric inflammation in Mongolian gerbils. One wk after intragastric inoculation with H. pylori, Mongolian gerbils were fed with either the control diet or the diet containing RGE (200 mg RGE/gerbil) for 6 wk. The following were determined in gastric mucosa: the number of viable H. pylori in stomach; MPO activity; LPO level; mRNA and protein levels of keratinocyte chemoattractant factor (KC, a rodent IL-8 homolog), IL-1b, and iNOS; protein level of phospho-IkBa (which reflects the activation of NF-kB); and histology. As a result, RGE suppressed H. pylori-induced mRNA and protein levels of KC, IL-1b, and iNOS in gastric mucosa. RGE also inhibited H. pylori-induced phosphorylation of IkBa and increases in LPO level and MPO activity of gastric mucosa. RGE did not affect viable H. pylori colonization in the stomach, but improved the histological grade of infiltration of polymorphonuclear neutrophils, intestinal metaplasia, and hyperplasia. In conclusion, RGE inhibits H. pyloriinduced gastric inflammation by suppressing induction of inflammatory mediators (KC, IL-1b, iNOS), MPO activity, and LPO level in H. pylori-infected gastric mucosa.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (51)
참고문헌 신청
1. [학술지(정기간행물)] - Blaser MJ / 1990 / Helicobacter pylori and the pathogenesis of gastroduodenal inflammation / J Infect Dis 161 : 626 ~ 633
2. [학술지(정기간행물)] - NIH Consensus Conference / 1994 / Helicobacter pylori in peptic ulcer disease. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease / J Am Med Assoc 272 : 65 ~ 69
3. [학술지(정기간행물)] - Amagase K / 2010 / New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils / J Pharmacol Sci 112 : 25 ~ 32
4. [학술지(정기간행물)] - Burdon RH / 1995 / Superoxide and hydrogen peroxide in relation to mammalian cell proliferation / Free Rad Biol Med 18 : 775 ~ 794
5. [학술지(정기간행물)] - Handa O / 2010 / Helicobacter pylori: a ROS-inducing bacterial species in the stomach / Inflamm Res 59 : 997 ~ 1003
2. [학술지(정기간행물)] - NIH Consensus Conference / 1994 / Helicobacter pylori in peptic ulcer disease. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease / J Am Med Assoc 272 : 65 ~ 69
3. [학술지(정기간행물)] - Amagase K / 2010 / New frontiers in gut nutrient sensor research: prophylactic effect of glutamine against Helicobacter pylori-induced gastric diseases in Mongolian gerbils / J Pharmacol Sci 112 : 25 ~ 32
4. [학술지(정기간행물)] - Burdon RH / 1995 / Superoxide and hydrogen peroxide in relation to mammalian cell proliferation / Free Rad Biol Med 18 : 775 ~ 794
5. [학술지(정기간행물)] - Handa O / 2010 / Helicobacter pylori: a ROS-inducing bacterial species in the stomach / Inflamm Res 59 : 997 ~ 1003
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UCI(KEPA) : I410-ECN-0101-2015-520-001297325