In the present study, performance of multi-stage centrifugal pump was analyzed with various blade angles to predict hydraulic head and flow rate. Rotation of impeller was simulated by the Multi Reference Frames (MRF) technique. The simulation was modeled three-dimensional internal flow with incompressible turbulence which was described by Realizable k-e turbulent model. The blade angle, the blade number and the outlet diameter of impeller are the most important factors to pump performance. In this study, the influence of blade angle on the performance and the efficiency of the pump examined. Hydraulic head, flow rate and torque were extracted by different blade angle. This numerical prediction of pump performance showed good agreement for experimental data. The results showed the specific range of blade angle to maximize performance and efficiency of multi-stage centrifugal pump.