지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 168 - 174 (7page)
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초록· 키워드
오류제보하기
Purpose: Seasonal and geographic variations in ultraviolet B intensities (UVB) impact the vitamin D status, and these differences might significantly affect cancer prognosis. This study evaluates the association between seasonal and geographic differences in UVB exposure and breast cancer survival.
Methods: We divided Korea into two regions according to erythemally weighted annual UVB exposure as follows: Seoul and the southern region. Recurrence and death were also grouped into two seasons: spring/summer and autumn/winter.
Results: The survival and relapse rates, when stratified by season of diagnosis, demonstrated no significant differences between spring/summer and autumn/winter. Among the 1,488 breast cancer patients in our cohort who demonstrated recurrence, 775 cases (52.1%) relapsed during the spring/summer and 594 patients (52.6%) died during the autumn/winter. In total, 6,178 patients (89.1%) and 3,909 patients (91.3%) in Seoul and the southern region survived (P=0.005). The relapse rate in the Seoul group (13.7%) was higher than the southern group (11.9%). By Kaplan-Meier analysis, there were no statistical differences between the Seoul and southern groups in terms of disease-free (P=0.43) and cancer-specific survival (P=0.18). In the Cox analysis, after the adjustment of all the other factors, season of diagnosis and residential area have no statistical significance.
Conclusion: We conclude from our findings that death from breast cancer occurs more frequently in the autumn/winter, and that patients in the southern area of Korea demonstrate better survival. However, we find no significant relationship between geographic and seasonal variations in breast cancer survival.
Methods: We divided Korea into two regions according to erythemally weighted annual UVB exposure as follows: Seoul and the southern region. Recurrence and death were also grouped into two seasons: spring/summer and autumn/winter.
Results: The survival and relapse rates, when stratified by season of diagnosis, demonstrated no significant differences between spring/summer and autumn/winter. Among the 1,488 breast cancer patients in our cohort who demonstrated recurrence, 775 cases (52.1%) relapsed during the spring/summer and 594 patients (52.6%) died during the autumn/winter. In total, 6,178 patients (89.1%) and 3,909 patients (91.3%) in Seoul and the southern region survived (P=0.005). The relapse rate in the Seoul group (13.7%) was higher than the southern group (11.9%). By Kaplan-Meier analysis, there were no statistical differences between the Seoul and southern groups in terms of disease-free (P=0.43) and cancer-specific survival (P=0.18). In the Cox analysis, after the adjustment of all the other factors, season of diagnosis and residential area have no statistical significance.
Conclusion: We conclude from our findings that death from breast cancer occurs more frequently in the autumn/winter, and that patients in the southern area of Korea demonstrate better survival. However, we find no significant relationship between geographic and seasonal variations in breast cancer survival.
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INTRODUCTION
METHODS
RESULTS
DISCUSSION
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UCI(KEPA) : I410-ECN-0101-2015-510-001101520