Calcium phosphate such as Hydroxyapatite (HA) and beta tri-calcium phosphate (β-TCP), due to its excellent biocompatibility and bioactivity, is widely used in the clinic of orthopedic as well as dental applic ations. The HA h as g ood biologic al p roperties like n on-immunogenicity, n on-inflammatory behavior, high osteoconductivity and osteoinductivity. The β-TCP shows the good biocompatibility and biodegradability. Especially, calcium phosphate scaffolds have interconnected pores that provide a favorable environment for bone i ngrowth, o sseointegration a nd b lood s upply. T he c alc ium phosphate sc affold, however, h as brittle property and low strength. The purpose of this study was to investigate the effects of a kind and each amount of binder and fabrication methods for high compressive strength of calcium phosphate scaffold. At HA scaffold, the maximum compressive strength was performed when combined binder of 3 wt% of polyvinyl alcohol and 1 wt% of methyl cellulose was selected. The β-TCP scaffold fabricated by novel template- casting has high compressive strength than sponge method.