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자료유형
학술저널
저자정보
Hyun-Jung Chae (Inha University) Jung-Eun Yim (Changwon National University) Kyung-Ah Kim (Kyung Hee University) Jong-Hee Chyun (Inha University)
저널정보
한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.8 No.1
발행연도
2014.2
수록면
40 - 45 (6page)

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초록· 키워드

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As well-being foods pursuing healthy life are becoming popular, interest in Rubus coreanus Miquel (RCM) fruit, a type of Korean blackberry, is increasing due to its medicinal actions including protecting the liver, brightening the eyes, and alleviating diabetes. This study was carried out to evaluate the hepatoprotective effects of RCM concentrates on liver injuries induced by carbon tetrachloride (CCl<SUB>4</SUB>) in rats. RCM, produced in June ~ July 2008 at Chunbook, Gochang (South Korea), was finely mashed. The seeds were removed and the juices were condensed. Thirty-two Sprague-Dawley rats were divided into four groups according to treatment: normal (eight rats), CCl<SUB>4</SUB>, 1% RCM, and 2% RCM. Experimental diets were provided to the experimental animals for 4 weeks. We measure total cholesterol, high density lipoprotein-cholesterol (HDL-C), aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP) levels. Part of the livers was isolated for histopathological evaluation, and analyzed for lipid peroxide (TBARS), superoxide dismutase (SOD) and liver proteins. The activities of serum AST, ALT, and ALP were elevated following CCl<SUB>4</SUB> administration. Levels of hepatic TBARS were also significantly increased in the CCl<SUB>4</SUB> groups. However, hepatic TBARS levels and the activities of serum enzymes were markedly reduced by supplementation with the RCM concentrates (P < 0.05). Hepatic SOD activity increased in the RCM concentrates group versus CCl<SUB>4</SUB> groups. Histopathological examination revealed massive necrosis in the centrilobular area and degenerative changes caused by CCl<SUB>4</SUB> were ameliorated by dietary supplementation with RCM concentrates. These results suggest that RCM concentrates have hepatoprotective effects and may improve the symptoms of liver injuries.

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Abstract
Introduction
Materials and Methods
Results
Discussion
References

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