Purpose: This study was done to identify the influences of ego resilience and communication ability on problem-solving ability in nursing students. Methods: The subjects consisted of 448 first and second year nursing students. The data were collected from June 10 to 21, 2013. The data were analyzed using t-test, ANOVA, Scheffe’s test, Pearson’s correlation coefficients and multiple linear regression with IBM SPSS Statistics version 19.0. Results: The Ego resilience score of subjects was 2.84 out of a perfect score of 4, the communication ability score of subjects was 3.51, and the problem-solving ability score of subjects was 3.44 out of a perfect score of 5. A positive correlation was found for problem-solving ability with ego resilience and communication ability. The strongest predictor of problem-solving ability was a communication ability. Conclusion: These findings indicate that there is a need to increase communication ability to improve the problem-solving ability of nursing students. The results should be reflected in the development of effective curricula.