지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 1,205 - 1,215 (11page)
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초록· 키워드
오류제보하기
If peripheral nerve injured, nerve fibers distal to the lesion degenerate by the process known as Wallerian degeneration. Wallerian degeneration leads to the removal of axonal and myelin-derived debris, and prepares the environment for regenerating axons grow. To clean up the debris, macrophages are recruited in the injury sites. We investigate the effect of treadmill exercise to macrophages and their biomarker MCP1 expression level. To investigate the recruited macrophage and re-generated degree of nerve, we did immunohistochemistry and real time PCR. Also to investigate the nerve regeneration, we did electromyography(EMG)and electron Micrograph(EM) analysis. We detected that treadmill exercise increase the macrophage numbers and their biomarker MCP1 expression level. Also, it enhance the nerve regenerating signals (cMAP, distal latency and morphological markers etc.). These results demonstrate that aerobic exercise, such as treadmill exercise, enhance the nerve regeneration by induce the wallrian degeneration(recruit the macrophages) in the nerve regeneration mice model.
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 논의
Ⅳ. 결론
참고문헌
참고문헌 (18)
참고문헌 신청
1. [학술지(정기간행물)] - Boschi, E. / 1962 / Wallerian degeneration and regeneration of the peripheral nerve under the influence of antimitotic agents / Sist Nerv 14 : 325 ~ 344
2. [학술지(정기간행물)] - Brushart, T. M. / 1998 / Contributions of pathway and neuron to preferential motor reinnervation / J Neurosci 18 (21) : 8674 ~ 8681
3. [학술지(정기간행물)] - Brushart, T. M. / 2005 / Electrical stimulation restores the specificity of sensory axon regeneration / Exp Neurol 194 (1) : 221 ~ 229
4. [학술지(정기간행물)] - Chen, L. / 2011 / Axon regeneration mechanisms : insights from C. elegans / Trends Cell Biol 21 (10) : 577 ~ 584
5. [학술지(정기간행물)] - Clark, B. D. / 2004 / Performance of a high-repetition, high-force task induces carpal tunnel syndrome in rats / J Orthop Sports Phys Ther 34 (5) : 244 ~ 253
2. [학술지(정기간행물)] - Brushart, T. M. / 1998 / Contributions of pathway and neuron to preferential motor reinnervation / J Neurosci 18 (21) : 8674 ~ 8681
3. [학술지(정기간행물)] - Brushart, T. M. / 2005 / Electrical stimulation restores the specificity of sensory axon regeneration / Exp Neurol 194 (1) : 221 ~ 229
4. [학술지(정기간행물)] - Chen, L. / 2011 / Axon regeneration mechanisms : insights from C. elegans / Trends Cell Biol 21 (10) : 577 ~ 584
5. [학술지(정기간행물)] - Clark, B. D. / 2004 / Performance of a high-repetition, high-force task induces carpal tunnel syndrome in rats / J Orthop Sports Phys Ther 34 (5) : 244 ~ 253
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UCI(KEPA) : I410-ECN-0101-2015-690-001009128