지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 257 - 261 (5page)
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초록· 키워드
오류제보하기
α-Curcumene is one of the physiologically active components of Curcuma zedoaria, which is believed to perform anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we investigated the mechanism of the apoptotic effect of α-curcumene on the growth of human overian cancer, SiHa cells. Upon treatment with α-curcumene, cell viability of SiHa cells was inhibited > 73% for 48 h incubation. α-Curcumene treatment showed a characteristic nucleosomal DNA fragmentation pattern and the percentage of sub-diploid cells was increased in a concentration-dependent manner, hallmark features of apoptosis. Mitochondrial cytochrome c activation and an in vitro caspase-3 activity assay demonstrated that the activation of caspases accompanies the apoptotic effect of α-curcumene, which mediates cell death. These results suggest that the apoptotic effect of α-curcumene on SiHa cells may converge caspase-3 activation through the release of mitochondrial cytochrome c.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Lobo, R. / 2009 / Curcuma zedoaria Rosc, (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties / J. Pharm. Pharmacol. 61:13~21
Moon, C. K. / 1985 / Antitumor activities of several phytopolysaccharides / Arch. Pham. Res. 8:42~44
Kim, K. I. / 2000 / Antitumor, genotoxicity and anticlastogenic activities of polysaccharide from Curcuma zedoaria / Mol. Cells 10:392~398
Syu, W. J. / 1998 / Cytotoxicity of curcuminoids and some novel compounds from Curcuma doaria / J. Nat. Prod. 61:1531~1534
Lay, E. Y. / 2004 / Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria / Am. J. Chin. Med. 32:281~290
Moon, C. K. / 1985 / Antitumor activities of several phytopolysaccharides / Arch. Pham. Res. 8:42~44
Kim, K. I. / 2000 / Antitumor, genotoxicity and anticlastogenic activities of polysaccharide from Curcuma zedoaria / Mol. Cells 10:392~398
Syu, W. J. / 1998 / Cytotoxicity of curcuminoids and some novel compounds from Curcuma doaria / J. Nat. Prod. 61:1531~1534
Lay, E. Y. / 2004 / Antimicrobial activity and cytotoxicity of the essential oil of Curcuma zedoaria / Am. J. Chin. Med. 32:281~290
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UCI(KEPA) : I410-ECN-0101-2015-510-001071769