지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 241 - 247 (7page)
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초록· 키워드
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This study was carried out to examine the action mechanism of Chamaecyparis obtusa oil (CO) on hair growth in C57BL/6 mice. For alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GT) activities in the skin tissue, at week 4, the 3% minoxidil (MXD) and 3% CO treatment groups showed an ALP activity that was significantly higher by 85% (p < 0.001) and 48% (p < 0.05) and an γ-GT activity that was significantly higher by 294% (p < 0.01) and 254% (p < 0.05) respectively, as compared to the saline (SA) treatment group. For insulin-like growth factor-1 (IGF-1) mRNA expression in the skin tissue, at week 4, the MXD and CO groups showed a significantly higher expression by 204% (p < 0.05) and 426% (p < 0.01) respectively, as compared to the SA group. At week 4, vascular endothelial growth factor (VEGF) expression in the MXD and CO groups showed a significantly higher expression by 74% and 96% (p < 0.05) respectively, however, epidermal growth factor (EGF) expression in the MXD and CO groups showed a significantly lower expression by 66% and 61% (p < 0.05) respectively, as compared to the SA group. Stem cell factor (SCF) expression in the MXD and CO groups was observed by immunohistochemistry as significant in a part of the bulge around the hair follicle and in a part of the basal layer of the epidermis. Taking all the results together, on the basis of effects on ALP and γ-GT activity, and the expression of IGF-1, VEGF and SCF, which are related to the promotion of hair growth, it can be concluded that CO induced a proliferation and division of hair follicle cells and maintained the anagen phase. Because EGF expression was decreased significantly, CO could delay the transition to the catagen phase.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
Paus, R. / 1999 / The biology of hair follicles / N. Engl. J. Med 341:491~497
Mak, K.K. / 2003 / Epidermal growth factor as a biologic switch in hair growth cycle / J. Biol. Chem. 278:26120~26126
Rückert, R. / 2000 / High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivo / Br. J. Dermatol. 143:1036~1039
Hibino, T. / 2004 / Role of TGF-β2 in the human hair cycle / J. Dermatol. Sci. 35:9~18
Krause, K. / 2006 / Biology of the hair follicle: the basics / Semin. Cutaneous Med. Surg. 25:2~10
Mak, K.K. / 2003 / Epidermal growth factor as a biologic switch in hair growth cycle / J. Biol. Chem. 278:26120~26126
Rückert, R. / 2000 / High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivo / Br. J. Dermatol. 143:1036~1039
Hibino, T. / 2004 / Role of TGF-β2 in the human hair cycle / J. Dermatol. Sci. 35:9~18
Krause, K. / 2006 / Biology of the hair follicle: the basics / Semin. Cutaneous Med. Surg. 25:2~10
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UCI(KEPA) : I410-ECN-0101-2015-510-001071749