지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 1,508 - 1,512 (5page)
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초록· 키워드
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For the development of bacteria-encapsulated biodegradable and/or biocompatible microbeads for therapeutic bacteria delivery, we fabricated bacteria-encapsulated alginate microbeads through two types of droplet generation methods using a cross-junction microfluidic channel and an aeration device. The bacteria-encapsulated alginate microbeads were made from a mixture of 1% alginate and bacteria (OD<SUB>600</SUB>=1) solution. First, in the droplet generation using a microfluidic channel, the size of the microbeads was controlled by the regulation of the continuous phase flow rate in the microfluidic channel. Second, in the droplet generation using an aeration device, the size of the microbeads was also controlled by the regulation of the airflow in the aeration device and uniform microbeads can be obtained by filtration using even-sized pore containing membrane filter. For observation of bacterial growth in alginate microbeads, we fabricated alginate microbeads with diameter of 20 ± 5 μm by the microfluidic channel and the aeration device and observed the bacterial population in the bacteria-encapsulated alginate microbeads. Finally, it was observed that the encapsulated bacteria could be survived in the fabricated alginate microbeads. In addition, the encapsulate bacteria could be released from the alginate microbeads after the bacteria have reached the maximum population in alginate microbeads.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS
4. DISCUSSION
5. CONCLUSION
REFERENCES
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