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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 230 - 237 (8page)
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Amyloid β peptide (Aβ) still best known as a molecule to cause Alzheimer"s disease (AD). AD is characterized by the accumulation and deposition of Aβ within the brain, leading to neuronal cell loss and perturbation of synaptic function by causing free radical formation, inflammation and apoptosis. We investigated the inflammatory action of Aβ on two types of brain cells, neuronal cells (SH-SY5Y) and neuroglia cells (C6), and its mechanism. We measured the production of NO-iNOS, TNF-α, and ICAM-1 using RT-PCR and Western blot analysis less than the concentration of cytotoxic effects (> 70% survivability). Aβ had no effect on the production of NO and TNF-α, but significantly increases of iNOS and ICAM-1. Based on this, we suggest that the inflammatory effect of Aβ results from the action of ICAM-1 in neuronal cells, rather than the release of inflammatory mediators such as NO and TNF-α in neuroglia cells. In addition, we confirmed whether p53 was related to the action of Aβ by using SH-SY5Y (p53<SUP>-/-</SUP>) dominant cells. Neither the expressionof p53 nor the cytotoxicity of SH-SY5Y (p53<SUP>-/-</SUP>) cells were directly affected by Aβ. However, ICAM-1 was not expressed in SH-SY5Y (p53<SUP>-/-</SUP>) cells. This means that p53-independent pathway exists in the expression of ICAM-1 by Aβ while p53 plays a role as an on-and-off switch.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Pietrzik, C. / 2005 / Concepts for the treatment of Alzheimer’s disease: Molecular mechanisms and clinical application / Int. J. Exp. Pathol 86 : 173 ~ 185
2. [학술지(정기간행물)] - Silverberg, G. D. / 2004 / Novel ventriculo-peritoneal shunt in Alzheimer’s disease cerebrospinal fluid biomarkers / Expert Rev. Neurother 4 : 97 ~ 107
3. [학술지(정기간행물)] - Barril, X. / 2001 / Towards improved acetylcholinesterase inhibitors: A structural and computational approach / Mini Rev. Med. Chem 1 : 255 ~ 266
4. [학술지(정기간행물)] - Gong, Y. / 2003 / Alzheimer’s diseaseaffected brain: Presence of oligomeric A-beta ligands (ADDLs) suggests a molecular basis for reversible memory loss / Proc. Natl. Acad. Sci. USA 100 : 10417 ~ 10422
5. [학술지(정기간행물)] - Yankner, B. A. / 1990 / Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides / Science 250 : 279 ~ 282
2. [학술지(정기간행물)] - Silverberg, G. D. / 2004 / Novel ventriculo-peritoneal shunt in Alzheimer’s disease cerebrospinal fluid biomarkers / Expert Rev. Neurother 4 : 97 ~ 107
3. [학술지(정기간행물)] - Barril, X. / 2001 / Towards improved acetylcholinesterase inhibitors: A structural and computational approach / Mini Rev. Med. Chem 1 : 255 ~ 266
4. [학술지(정기간행물)] - Gong, Y. / 2003 / Alzheimer’s diseaseaffected brain: Presence of oligomeric A-beta ligands (ADDLs) suggests a molecular basis for reversible memory loss / Proc. Natl. Acad. Sci. USA 100 : 10417 ~ 10422
5. [학술지(정기간행물)] - Yankner, B. A. / 1990 / Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides / Science 250 : 279 ~ 282
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UCI(KEPA) : I410-ECN-0101-2014-400-003442043