지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 583 - 588 (6page)
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초록· 키워드
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To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.
목차
Abstract
REFERENCES
참고문헌 (22)
참고문헌 신청
Lee KH / 2008 / Immunization of proteins from Toxascaris leonina adult worm inhibits allergic specific Th2 response / Vet Parasitol 156:216~225
Roberts LS / 2009 / Foundations of Parasitology / McGraw-Hill
Nagy D / 2012 / Analysis of serum cytokine levels in children with chronic cough associated with Toxocara canis infection / Parasite Immunol 34:581~588
Takamoto M / 1998 / Eosinophilia, IgE production, and cytokine production by lung T cells in surface CD4-deficient mutant mice infected with Toxocara canis / Immunology 95:97~104
Torina A / 2005 / Toxocara canis infection induces antigen-specific IL-10 and IFN-gamma production in pregnant dogs and their puppies / Vet Immunol Immunopathol 108:247~251
Roberts LS / 2009 / Foundations of Parasitology / McGraw-Hill
Nagy D / 2012 / Analysis of serum cytokine levels in children with chronic cough associated with Toxocara canis infection / Parasite Immunol 34:581~588
Takamoto M / 1998 / Eosinophilia, IgE production, and cytokine production by lung T cells in surface CD4-deficient mutant mice infected with Toxocara canis / Immunology 95:97~104
Torina A / 2005 / Toxocara canis infection induces antigen-specific IL-10 and IFN-gamma production in pregnant dogs and their puppies / Vet Immunol Immunopathol 108:247~251
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UCI(KEPA) : I410-ECN-0101-2014-510-003484344