지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Journal of the Korean Surgical Society Vol.85 No.5
- 발행연도
- 2013.11
- 수록면
- 219 - 224 (6page)
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초록· 키워드
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Purpose: Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide.
Methods: Three groups, each having 8 rats, were formed within the scope of our study. Group I (the control group) only received laparatomy, group II received choledoch ligation, and group III was administered Flavanoid (90% flavonoid diosmin, 10% flavonoid hesperidin) following choledoch ligation. The rats were administered Flavanoid at week two following choledoch ligation. The rats’ livers and lungs were examined histopathologically following a five-week follow-up and the perialveolar vein diameters were measured. Arterial blood gases and biochemical parameters were evaluated.
Results: It was seen that fibrosis and oxidative damage in the liver with obstructive jaundice as well as hypoxia with pulmonary perialveolar vein sizes were significantly lower than the other group with cirrhosis formed through the administration of Flavanoid.
Conclusion: We have concluded that Flavanoid administration might be useful in the treatment of hypoxia in hepatopulmonary syndrome and the delay of cirrhosis contraction.
Methods: Three groups, each having 8 rats, were formed within the scope of our study. Group I (the control group) only received laparatomy, group II received choledoch ligation, and group III was administered Flavanoid (90% flavonoid diosmin, 10% flavonoid hesperidin) following choledoch ligation. The rats were administered Flavanoid at week two following choledoch ligation. The rats’ livers and lungs were examined histopathologically following a five-week follow-up and the perialveolar vein diameters were measured. Arterial blood gases and biochemical parameters were evaluated.
Results: It was seen that fibrosis and oxidative damage in the liver with obstructive jaundice as well as hypoxia with pulmonary perialveolar vein sizes were significantly lower than the other group with cirrhosis formed through the administration of Flavanoid.
Conclusion: We have concluded that Flavanoid administration might be useful in the treatment of hypoxia in hepatopulmonary syndrome and the delay of cirrhosis contraction.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Flukiger M. / 1884 / Vorkommen von Trommelschlagel-formigen Fingerend-phalangen ohne chronische Veranderungen an der Lungen oder an Herzen / Wien Med Wochenschr 34 : 1457 ~
2. [학술지(정기간행물)] - Kennedy TC / 1977 / Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis / Chest 72 : 305 ~ 309
3. [학술지(정기간행물)] - Krowka MJ / 1994 / Hepatopulmonary syndrome. Current concepts in diagnostic and therapeutic considerations / Chest 105 : 1528 ~ 1537
4. [학술지(정기간행물)] - Ho V. / 2008 / Current concepts in the management of hepatopulmonary syndrome / Vasc Health Risk Manag 4 : 1035 ~ 1041
5. [학술지(정기간행물)] - Fallon MB / 2005 / Mechanisms of pulmonary vascular complications of liver disease: hepatopulmonary syndrome / J Clin Gastroenterol 39 (4 Suppl 2) : S138 ~ S142
2. [학술지(정기간행물)] - Kennedy TC / 1977 / Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis / Chest 72 : 305 ~ 309
3. [학술지(정기간행물)] - Krowka MJ / 1994 / Hepatopulmonary syndrome. Current concepts in diagnostic and therapeutic considerations / Chest 105 : 1528 ~ 1537
4. [학술지(정기간행물)] - Ho V. / 2008 / Current concepts in the management of hepatopulmonary syndrome / Vasc Health Risk Manag 4 : 1035 ~ 1041
5. [학술지(정기간행물)] - Fallon MB / 2005 / Mechanisms of pulmonary vascular complications of liver disease: hepatopulmonary syndrome / J Clin Gastroenterol 39 (4 Suppl 2) : S138 ~ S142
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