지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.10
- 수록면
- 425 - 434 (10page)
이용수
초록· 키워드
오류제보하기
UV irradiation is the main factor contributing to skin damages that are associated with an excessive production of matrixdegrading metalloproteinase (MMP)-1 and a deficient expression of collagens. To date, red ginseng has been revealed to possess many biomedical effects, such as anti-aging, anti-oxidation, and anti-inflammatory. In this study, we prepared the Korean Red Ginseng extracts treated with enzyme (KRGE) and investigated the effects of dietary KRGE on the formation of wrinkles generated by UVB irradiation in hairless mice. It was found that KRGE inhibited the UVB-induced formation of wrinkles, epidermal thickness, and skin dryness in hairless mice. Further results also showed that KRGE attenuated UVB-induced MMP-1 level, while accelerated procollagen type I, transforming growth factor-β1 secretion. Interestingly, the expression of profilaggrin and filaggrin in both the epidermis and dermis were decreased due to UVB exposure and reversed by KRGE. The KRGE 0.06% was prior to KRGE 0.24%. In view of these results, which indicated that KRGE protected skin from UVB-induced photodamages, which may not only mediated by regulating of MMP-1 and procollagen type I, but also by increasing the production of profilaggrin and filaggrin. In conclusion, our results suggest that KRGE may be a promising agent for the treatment of skin photodamages. The challenge of KRGE will be expected as cosmeceuticals and nutraceuticals in order to intervene in aging-related degenerative skin changes.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - Farage MA / 2008 / Functional and physiological characteristics of the aging skin / Aging Clin Exp Res 20 : 195 ~ 200
2. [학술지(정기간행물)] - Miyauchi H / 1993 / The effect of ultraviolet radiation on the water-reservoir functions of the stratum corneum / Photodermatol Photoimmunol Photomed 9 : 193 ~ 197
3. [학술지(정기간행물)] - Tanaka H / 1993 / The effect of reactive oxygen species on the biosynthesis of collagen and glycosaminoglycans in cultured human dermal fibroblasts / Arch Dermatol Res 285 : 352 ~ 355
4. [학술지(정기간행물)] - Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138 : 1462 ~ 1470
5. [학술지(정기간행물)] - Hye Min Park / 2011 / Royal Jelly Protects Against Ultraviolet B–Induced Photoaging in Human Skin Fibroblasts via Enhancing Collagen Production / Journal of Medicinal Food 14 (9) : 899 ~ 906
2. [학술지(정기간행물)] - Miyauchi H / 1993 / The effect of ultraviolet radiation on the water-reservoir functions of the stratum corneum / Photodermatol Photoimmunol Photomed 9 : 193 ~ 197
3. [학술지(정기간행물)] - Tanaka H / 1993 / The effect of reactive oxygen species on the biosynthesis of collagen and glycosaminoglycans in cultured human dermal fibroblasts / Arch Dermatol Res 285 : 352 ~ 355
4. [학술지(정기간행물)] - Fisher GJ / 2002 / Mechanisms of photoaging and chronological skin aging / Arch Dermatol 138 : 1462 ~ 1470
5. [학술지(정기간행물)] - Hye Min Park / 2011 / Royal Jelly Protects Against Ultraviolet B–Induced Photoaging in Human Skin Fibroblasts via Enhancing Collagen Production / Journal of Medicinal Food 14 (9) : 899 ~ 906
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UCI(KEPA) : I410-ECN-0101-2014-520-002777911