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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.18 No.3
- 발행연도
- 2013.9
- 수록면
- 181 - 187 (7page)
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초록· 키워드
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Artemisia princeps Pampanini (AP) has been used as a traditional medicine in Korea, China and Japan and reported to exhibit various beneficial biological effects including anti-inflammatory, antioxidant, anti-atherogenic and lipid lowering activities; however, its antiplatelet and anticoagulant properties have not been studied. In the present study, we evaluated the effects of an ethanol extract of Artemisia princeps Pampanini (EAP) and its major flavonoids, eupatilin and jaceosidin, on platelet aggregation and coagulation. To determine the antiplatelet activity, arachidonic acid (AA)-, collagen-and ADP (adenosine diphosphate)-induced platelet aggregation were examined along with serotonin and thromboxane A₂ (TXA₂) generation in vitro. The anticoagulant activity was determined by monitoring the activated partial thromboplastin time (aPTT) and prothrombin time (PT) in vitro. The data showed that EAP and its major flavonoids, eupatilin and jaceosidin, significantly reduced AA-induced platelet aggregation and the generation of serotonin and TXA₂, although no significant change in platelet aggregation induced by collagen and ADP was observed. Moreover, EAP significantly
prolonged the PT and aPTT. The PT and/or aPTT were significantly increased in the presence of eupatilin and jaceosidin. Thus, these results suggest that EAP may have the potential to prevent or improve thrombosis by inhibiting platelet activation and blood coagulation.
prolonged the PT and aPTT. The PT and/or aPTT were significantly increased in the presence of eupatilin and jaceosidin. Thus, these results suggest that EAP may have the potential to prevent or improve thrombosis by inhibiting platelet activation and blood coagulation.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Yu HY / 2011 / Anti-platelet effects of yuzu extract and its component / Food Chem Toxicol 49 : 3018 ~ 3024
2. [학술지(정기간행물)] - Jennings LK / 2009 / Mechanisms of platelet activation : need for new strategies to protect against platelet-mediated atherothrombosis / Thrombo Haemost 102 : 248 ~ 257
3. [학술지(정기간행물)] - Hyun-Jeong Cho / 2009 / Inhibitory Effects of Oligopeptides from Hen Egg White on Both Human Platelet Aggregation and Blood Coagulation / Archives of Pharmacal Research 32 (6) : 945 ~ 953
4. [단행본] - Konkle BA / 2008 / Bleeding and thrombosis. In Harrison's principles of internal medicine / McGraw-Hill Professional : 363 ~ 369
5. [학술지(정기간행물)] - Son DJ / 2003 / Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid path way / J PLEFA 71 : 25 ~ 31
2. [학술지(정기간행물)] - Jennings LK / 2009 / Mechanisms of platelet activation : need for new strategies to protect against platelet-mediated atherothrombosis / Thrombo Haemost 102 : 248 ~ 257
3. [학술지(정기간행물)] - Hyun-Jeong Cho / 2009 / Inhibitory Effects of Oligopeptides from Hen Egg White on Both Human Platelet Aggregation and Blood Coagulation / Archives of Pharmacal Research 32 (6) : 945 ~ 953
4. [단행본] - Konkle BA / 2008 / Bleeding and thrombosis. In Harrison's principles of internal medicine / McGraw-Hill Professional : 363 ~ 369
5. [학술지(정기간행물)] - Son DJ / 2003 / Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid path way / J PLEFA 71 : 25 ~ 31
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UCI(KEPA) : I410-ECN-0101-2014-510-002839645