지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 174 - 177 (4page)
이용수
초록· 키워드
오류제보하기
Osteoporosis is a known major health problem and a serious disease of the bone, there has been a great need to develop more and newer animal models for this disease. Among animal models used for testing drug efficacy, the minipig model has become useful and effective due to its close similarity with humans (validity), particularly with the pharmacokinetics of compounds via subcutaneous administration, the structure and function of the organs, the morphology of bone and the overall metabolic nature. Based on these advantages, we sought to develop a new animal model of osteoporosis using micropig, which differs from other miniature pigs in the genetic background. Female micropigs were used for the induction of a moderate osteoporosis model by bilateral ovariectomy (OVX) and compared with shamoperated animals. For osteoporosis evaluation, clinical biomarkers such as blood osteocalcin (OSC) and parathyroid hormone (PTH) levels were measured, as well as bone mineral density (BMD) using microcomputed tomography (micro-CT). Compared to sham, OVX animals have decreased blood OSC level, while the blood PTH level increased in blood sera. In addition, we observed the significantly decreased BMDs of tibia region in OVX animals. Based on these results, we report that the micropig model developed in this study can be used to develop a new and effective medical method for diagnosis and treatment of osteoporosis.
목차
References
참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Miller ER / 1987 / The pig as a model for human nutrition / Annu Rev Nutr 7 : 361 ~ 382
2. [학술지(정기간행물)] - Hönig JF / 1993 / Subperiosteal versus epiperiosteal forehead augmentation with hydroxylapatite for aesthetic facial contouring: experimental animal investigation and clinical application / Aesthetic Plastic Surg 17 (2) : 93 ~ 98
3. [학술지(정기간행물)] - Swindle MM / 1998 / Comparative anatomy and physiology of the pig / Scand J Lab Anim Sci 25 : 11 ~ 21
4. [학술지(정기간행물)] - Scholz-Ahrens KE / 2007 / Glucocorticosteroid-induced osteoporosis in adult primiparous Göttingen miniature pigs: effects on bone mineral and mineral metabolism / Am J Physiol Endocrinol Metab 293 (1) : 385 ~ 395
5. [학술지(정기간행물)] - Akahoshi S / 2005 / Modulation of bone turnover by alfacalcidol and/or alendronate does not prevent glucocorticoidinduced osteoporosis in growing minipigs / J Bone Miner Metab 23 (5) : 341 ~ 350
2. [학술지(정기간행물)] - Hönig JF / 1993 / Subperiosteal versus epiperiosteal forehead augmentation with hydroxylapatite for aesthetic facial contouring: experimental animal investigation and clinical application / Aesthetic Plastic Surg 17 (2) : 93 ~ 98
3. [학술지(정기간행물)] - Swindle MM / 1998 / Comparative anatomy and physiology of the pig / Scand J Lab Anim Sci 25 : 11 ~ 21
4. [학술지(정기간행물)] - Scholz-Ahrens KE / 2007 / Glucocorticosteroid-induced osteoporosis in adult primiparous Göttingen miniature pigs: effects on bone mineral and mineral metabolism / Am J Physiol Endocrinol Metab 293 (1) : 385 ~ 395
5. [학술지(정기간행물)] - Akahoshi S / 2005 / Modulation of bone turnover by alfacalcidol and/or alendronate does not prevent glucocorticoidinduced osteoporosis in growing minipigs / J Bone Miner Metab 23 (5) : 341 ~ 350
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UCI(KEPA) : I410-ECN-0101-2014-500-002858175