지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 168 - 173 (6page)
이용수
초록· 키워드
오류제보하기
The integration of metabolism and reproduction involves complex interactions of hypothalamic neuropeptides with metabolic hormones, fuels, and sex steroids. Of these, estrogen influences food intake, body weight, and the accumulation and distribution of adipose tissue. In this study, the effects of estrogen on food intake, serum leptin levels, and leptin mRNA expression were evaluated in ovariectomized rats. Seven-week-old female Wistar-Imamichi rats were ovariectomized and divided into three treatment groups: group 1 (the control group) received sesame oil, group 2 was given 17β-estradiol benzoate, and group 3 received 17β-estradiol benzoate plus progesterone. The body weight and food consumption of each rat were determined daily. Serum leptin levels and leptin mRNA expression were measured by ELISA and quantitative RT-PCR, respectively. Food consumption in the control group was significantly higher (P<0.05) than that in groups 2 and 3, although body weight did not significantly differ among the three groups. The serum leptin concentration and leptin mRNA expression were significantly higher (P<0.05) in groups 2 and 3 than in group 1, but no significant difference existed between groups 2 and 3. In conclusion, estrogen influenced food intake via the modulation of leptin signaling pathway in ovariectomized rats.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Zhang Y / 1994 / Positional cloning of the mouse obese gene and its human homologue / Nature 372 (6505) : 425 ~ 432
2. [학술지(정기간행물)] - Watanobe H / 1999 / A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats / Biochem Biophys Res Commun 259 (1) : 56 ~ 59
3. [학술지(정기간행물)] - Mohamed WF / 2004 / Effect of gonadal sex steroid on serum leptin level of both adult male and female rat / Sci J King Faisal Univ (Basic Appl Sci) 5 : 239 ~ 247
4. [학술지(정기간행물)] - Stephens TW / 1995 / The role of neuropeptide Y in the antiobesity action of the obese gene product / Nature 377 (6549) : 530 ~ 532
5. [학술지(정기간행물)] - Halaas JL / 1995 / Weightreducing effects of the plasma protein encoded by the obese gene / Science 269 (5223) : 543 ~ 546
2. [학술지(정기간행물)] - Watanobe H / 1999 / A detailed study on the role of sex steroid milieu in determining plasma leptin concentrations in adult male and female rats / Biochem Biophys Res Commun 259 (1) : 56 ~ 59
3. [학술지(정기간행물)] - Mohamed WF / 2004 / Effect of gonadal sex steroid on serum leptin level of both adult male and female rat / Sci J King Faisal Univ (Basic Appl Sci) 5 : 239 ~ 247
4. [학술지(정기간행물)] - Stephens TW / 1995 / The role of neuropeptide Y in the antiobesity action of the obese gene product / Nature 377 (6549) : 530 ~ 532
5. [학술지(정기간행물)] - Halaas JL / 1995 / Weightreducing effects of the plasma protein encoded by the obese gene / Science 269 (5223) : 543 ~ 546
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-500-002858160