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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 148 - 155 (8page)
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초록· 키워드
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In the present study, we investigated the effect of Tetaus toxin (TeT) on cell proliferation and neuroblast differentiation using specific markers: 5-bromo-2-deoxyuridine (BrdU) as an exogenous marker for cell proliferation, Ki-67 as an endogenous marker for cell proliferation and doublecortin (DCX) as a marker for neuroblasts in the mouse hippocampal dentate gyrus (DG) after TeT treatment. Mice were intraperitoneally administered 2.5 and 10 ng/kg TeT and sacrificed 15 days after the treatment. In both the TeT-treated groups, no neuronal death occurred in any layers of the DG using neuronal nuclei (NeuN, a neuron nuclei maker) and Fluoro-Jade B (F-J B, a high-affinity fluorescent marker for the localization of neuronal degeneration). In addition, no significant change in glial activation in both the 2.5 and 10 ng/kg TeT-treated-groups was found by GFAP (a marker for astrocytes) and Iba-1 (a marker for microglia) immunohistochemistry. However, in the 2.5 ng/kg TeT-treated-group, the mean number of BrdU, Ki-67 and DCX immunoreactive cells, respectively, were apparently decreased compared to the control group, and the mean number of each in the 10 ng/kg TeT-treated-group was much more decreased. In addition, processes of DCX-immunoreactive cells, which projected into the molecular layer, were short compared to those in the control group. In brief, our present results show that low dosage (10 ng/kg) TeT treatment apparently decreased cell proliferation and neuroblast differentiation in the mouse hippocampal DG without distinct gliosis as well as any loss of adult neurons.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (43)
참고문헌 신청
1. [학술지(정기간행물)] - Colditz MJ / 2010 / p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis / Exp Brain Res 200 (2) : 161 ~ 167
2. [학술지(정기간행물)] - Helfer JL / 2009 / The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt / Brain Res 1294 : 1 ~ 11
3. [학술지(정기간행물)] - Li WL / 2011 / The role of VEGF/VEGFR2 signaling in peripheral stimulation-induced cerebral neurovascular regeneration after ischemic stroke in mice / Exp Brain Res 214 (4) : 503 ~ 513
4. [학술지(정기간행물)] - Shook BA / 2012 / Spatiotemporal changes to the subventricular zone stem cell pool through aging / J Neurosci 32 (20) : 6947 ~ 6956
5. [학술지(정기간행물)] - Crews FT / 2009 / Impulsivity, frontal lobes and risk for addiction / Pharmacol Biochem Behav 93 (3) : 237 ~ 247
2. [학술지(정기간행물)] - Helfer JL / 2009 / The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt / Brain Res 1294 : 1 ~ 11
3. [학술지(정기간행물)] - Li WL / 2011 / The role of VEGF/VEGFR2 signaling in peripheral stimulation-induced cerebral neurovascular regeneration after ischemic stroke in mice / Exp Brain Res 214 (4) : 503 ~ 513
4. [학술지(정기간행물)] - Shook BA / 2012 / Spatiotemporal changes to the subventricular zone stem cell pool through aging / J Neurosci 32 (20) : 6947 ~ 6956
5. [학술지(정기간행물)] - Crews FT / 2009 / Impulsivity, frontal lobes and risk for addiction / Pharmacol Biochem Behav 93 (3) : 237 ~ 247
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UCI(KEPA) : I410-ECN-0101-2014-500-002858135