지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.9
- 수록면
- 173 - 179 (7page)
이용수
초록· 키워드
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In-utero exposure to valproic acid (VPA) has been known as a potent inducer of autism spectrum disorder (ASD), not only in humans, but also in animals. In addition to the defects in communication and social interaction as well as repetitive behaviors, ASD patients usually suffer from gastrointestinal (GI) problems. However, the exact mechanism underlying these disorders is not known. In this study, we examined the gross GI tract structure and GI motility in a VPA animal model of ASD. On embryonic day 12 (E12), 4 pregnant Sprague-Dawley (SD) rats were subcutaneously injected with VPA (400 mg/kg) in the treatment group, and with phosphate buffered saline (PBS) in the control group; the resulting male offspring were analyzed at 4 weeks of age. VPA exposure decreased the thickness of tunica mucosa and tunica muscularis in the stomach and ileum. Other regions such as duodenum, jejunum, and colon did not show a significant difference. In high-resolution microscopic observation, atrophy of the parietal and chief cells in the stomach and absorptive cells in the ileum was observed. In addition, decreased staining of the epithelial cells was observed in the hematoxylin and eosin (H&E)-stained ileum section. Furthermore, decreased motility in GI tract was also observed in rat offspring prenatally exposed to VPA. However, the mechanism underlying GI tract defects in VPA animal model as well as the association between abnormal GI structure and function with ASD is yet to be clearly understood. Nevertheless, the results from the present study suggest that this VPA ASD model undergoes abnormal changes in the GI structure and function, which in turn could provide beneficial clues pertaining to the pathophysiological relevance of GI complications and ASD phenotypes.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
Lindhout, D. / 1986 / In-utero exposure to valproate and neural tube defects / Lancet 1:1392~1393
Williams, G. / 2001 / Fetal valproate syndrome and autism: additional evidence of an association / Dev. Med. Child. Neurol. 43:202~206
Kim, K. C. / 2011 / The critical period of valproate exposure to induce autistic symptoms in Sprague- Dawley rats / Toxicol. Lett. 201:137~142
Schneider, T. / 2005 / Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism / Neuropsychopharmacology 30:80~89
Valicenti-McDermott, M. / 2006 / Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease / J. Dev. Behav. Pediatr. 27:S128~S136
Williams, G. / 2001 / Fetal valproate syndrome and autism: additional evidence of an association / Dev. Med. Child. Neurol. 43:202~206
Kim, K. C. / 2011 / The critical period of valproate exposure to induce autistic symptoms in Sprague- Dawley rats / Toxicol. Lett. 201:137~142
Schneider, T. / 2005 / Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism / Neuropsychopharmacology 30:80~89
Valicenti-McDermott, M. / 2006 / Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease / J. Dev. Behav. Pediatr. 27:S128~S136
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UCI(KEPA) : I410-ECN-0101-2014-510-002864088