지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 248 - 254 (7page)
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Various biometerials have been researched and have been developed for treatment of some disease through transplantation to body. They have been evaluated by in vitro cytotoxicity test using some skin-derived cell lines for prediction of their biocompatibility in vivo. However, the results of experiments using mesenchymal or epithelial cells could not be considered in vivo immune reaction. In this study, we evaluated the biomaterial-elution (elute from high density polyethylene film) using some cell lines (L929, Jurkat, U937) in vitro, and then that results were compared with in vivo results from guinea pig sensitization test. In sensitization test, saline and elution of syringe could not induce erythema, but only DNCB (hypersensitive chemical) induce erythema at guinea pig sensitization test. In cell experiment, the cytotoxicity results of inflammatory cells (Jurkat; T lymphocyte, U937; monocyte) was no difference with L929 (fibroblast) in the overall trend. However, inflammatory cell lines were only secreted inflammatory cytokine (TNF-α, INF-γ) in some materials (biomateriallution, FAC, DNCB). And the biomaterial-elution did not have toxicity to the cells, but it induced the inflammatory cytokines in inflammatory cell lines only. So, we were predicted inflammatory reaction through the cytokine resultes of inflammatory cell lines, and it was more correlated with in vivo results than cytotoxicity test. Therefore, we suggested that the inflammatory cytokine assay using inflammatory cell lines are more effective method in vitro for evaluation of biocompatibility of biomaterials or chemicals.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
References
참고문헌 (23)
참고문헌 신청
1. [인터넷자원] - / / Wikipedia, the free encyclopedia
2. [학술지(정기간행물)] - Kimber, I / 2001 / Alternative approaches to the identification and characterization of chemical allergens / Toxicol. In Vitro 15 : 307 ~ 312
3. [학술지(정기간행물)] - Steiling, W / 2001 / Skin sensitisation testing-new perspectives and recommendations / Food Chem. Toxicol 39 : 293 ~ 301
4. [학술지(정기간행물)] - Kay, A. B / 2000 / Overview of ‘allergy and allergic diseases: with a view to the future’ / Br. Med. Bull 56 : 843 ~ 864
5. [학술지(정기간행물)] - Cavani, A / 2001 / Effector and regulatory T cells in allergic contact dermatitis / Trends Immunol 22 : 118 ~ 120
2. [학술지(정기간행물)] - Kimber, I / 2001 / Alternative approaches to the identification and characterization of chemical allergens / Toxicol. In Vitro 15 : 307 ~ 312
3. [학술지(정기간행물)] - Steiling, W / 2001 / Skin sensitisation testing-new perspectives and recommendations / Food Chem. Toxicol 39 : 293 ~ 301
4. [학술지(정기간행물)] - Kay, A. B / 2000 / Overview of ‘allergy and allergic diseases: with a view to the future’ / Br. Med. Bull 56 : 843 ~ 864
5. [학술지(정기간행물)] - Cavani, A / 2001 / Effector and regulatory T cells in allergic contact dermatitis / Trends Immunol 22 : 118 ~ 120
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UCI(KEPA) : I410-ECN-0101-2014-400-002390633