지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 183 - 188 (6page)
이용수
초록· 키워드
오류제보하기
Adult stem cells, which have characteristic of self-renewal and multipotency, are specialized cell types, responsible for the tissue regeneration of the damaged tissue. Recent studies suggest that stem cells senescence (or stem cells’ ageing) is closely associated with the variety of ageing-related phenotypes such as tissue atrophy, degenerative diseases and onset of cancers. During ageing, declining of stem cells function and subsequently occurring mal-differentiation of stem cells would be important to understand the biological process of development of ageing-related phenotypes such as tissue degenerations and cancers. This review focuses on the DNA damage stress as a cause of senescence of stem cells and their maldifferentiation, which is closely link to defect of regeneration potentials and neoplastic transformation. Understanding of molecular mechanisms governingsuch events is likely to have important implications for developing novel avenues for balancing tissue homeostasis longer period of time, further leading to ‘Healthy ageing’.
목차
Abstract
1. 서론
2. 성체줄기세포 특성
3. 결론
References
참고문헌 (58)
참고문헌 신청
1. [학술지(정기간행물)] - Van Zant, G / 2003 / The role of stem cells in aging / Exp. Hematol 31 : 659 ~ 672
2. [학술지(정기간행물)] - Snyder, E. Y / 2005 / A role for stem cell biology in the physiological and pathological aspects of aging / J. Am. Geriatr 53 : 287 ~ 291
3. [학술지(정기간행물)] - Flores, I / 2008 / The longest telomeres: a general signature of adult stem cell compartments / Genes Dev 22 : 654 ~ 667
4. [학술지(정기간행물)] - Finkel, T. / 2007 / The common biology of cancer and ageing / Nature 448 : 767 ~ 774
5. [학술지(정기간행물)] - Rando, T. A / 2006 / Stem cells, ageing and the quest for immortality / Nature 441 : 1080 ~ 1086
2. [학술지(정기간행물)] - Snyder, E. Y / 2005 / A role for stem cell biology in the physiological and pathological aspects of aging / J. Am. Geriatr 53 : 287 ~ 291
3. [학술지(정기간행물)] - Flores, I / 2008 / The longest telomeres: a general signature of adult stem cell compartments / Genes Dev 22 : 654 ~ 667
4. [학술지(정기간행물)] - Finkel, T. / 2007 / The common biology of cancer and ageing / Nature 448 : 767 ~ 774
5. [학술지(정기간행물)] - Rando, T. A / 2006 / Stem cells, ageing and the quest for immortality / Nature 441 : 1080 ~ 1086
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-400-002390522