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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 293 - 299 (7page)
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초록· 키워드
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PEGylation, the attachment of polyethylene glycol (PEG) to proteins, is currently main technology for improving efficacy of protein drugs. This technology can prolong the plasma half-life, augment the in vivo stability, and diminish the immunogenicity of therapeutic proteins. Therefore, PEGylated proteins have the enhanced therapeutic efficacy and the reduced undesirable effects versus their native therapeutics. Since the first PEGylated protein product appeared on the market in the early 1990s, currently ten PEGylated protein products have been launched. These marketed drug products have proved the applicability and safety of the PEGylation technology. This review presents overview of PEGylation technology and addresses characteristics of PEGylation methods applied for the development of several protein drugs.
목차
Abstract
1. 서론
2. PEGylation 효과
3. PEG의 특성과 유도체
4. 주요 PEG-단백질 의약품
5. 결론
References
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Lawrence, S / 2007 / Billion dollar babies-biotech drugs as blockbusters / Nature Biotech 25 : 380 ~ 382
2. [학술지(정기간행물)] - Abuchowski, A / 1977 / Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase / J. Biol. Chem 252 : 3582 ~ 3586
3. [학술지(정기간행물)] - Abuchowski, A. / 1977 / Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol / J. Biol. Chem 252 : 3578 ~ 3581
4. [학술지(정기간행물)] - Veronese, F. M / 2008 / The impact of PEGylation on biological therapies / BioDrugs 22 : 315 ~ 329
5. [학술지(정기간행물)] - Kang, J. S. / 2009 / Emerging PEGylated drugs / Expert Opin. Emerg. Drugs 14 : 363 ~ 380
2. [학술지(정기간행물)] - Abuchowski, A / 1977 / Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase / J. Biol. Chem 252 : 3582 ~ 3586
3. [학술지(정기간행물)] - Abuchowski, A. / 1977 / Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol / J. Biol. Chem 252 : 3578 ~ 3581
4. [학술지(정기간행물)] - Veronese, F. M / 2008 / The impact of PEGylation on biological therapies / BioDrugs 22 : 315 ~ 329
5. [학술지(정기간행물)] - Kang, J. S. / 2009 / Emerging PEGylated drugs / Expert Opin. Emerg. Drugs 14 : 363 ~ 380
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UCI(KEPA) : I410-ECN-0101-2014-400-002406021