지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.8
- 수록면
- 283 - 292 (10page)
이용수
초록· 키워드
오류제보하기
Solid dispersion is one of well-established pharmaceutical techniques to improve the dissolution and consequent bioavailability of poorly water soluble drugs. It is defined as a dispersion of drug in an inert carrier matrix. Solid dispersions can be classified into three generations according to the carrier used in the system. First and second generations consist of crystalline and amorphous substances, respectively. Third generation carriers are surfactant, mixture of polymer and surfactants, and mixture of polymers. Solid dispersions can be generallyprepared by melting method and solvent method. While melting method requires high temperature to melt carrier and dissolve drug, solvent method utilizes solvent to dissolve the components. The improvement in dissolution through solid dispersions is attributed to reduction in drug particle size, improvement in wettability, and/or formation of amorphous state. The primary characteristics of solid dispersions, the presenceof drug in amorphous state, could be determined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and fourier-transformed infrared spectroscopy (FTIR). In spite of the significant improvement in dissolution by solid dispersion technique, some drawbacks have limited the commercial application of solid dispersions. Thus, further studies should be conducted in a direction to improve the congeniality to commercialization.
목차
Abstract
1. Introduction
2. Classification of solid dispersions
3. Mechanism of dissolution enhancement
4. Methods of manufacture
5. Characterization of solid dispersions
6. Limitations of solid dispersions
7. Recent and future strategies to overcome thedrawbacks
8. Conclusions
References
참고문헌 (90)
참고문헌 신청
1. [학술지(정기간행물)] - Fasano, A / 1998 / Novel approaches in oral delivery of macromolecules / J. Pharm. Sci 87 : 1351 ~ 1356
2. [학술지(정기간행물)] - Youn, Y. S. / 2006 / Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy / J. Control Rel 114 : 334 ~ 342
3. [학술지(정기간행물)] - Sugawara, M. / 2005 / The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations / Eur. J. Pharm. Sci 26 : 1 ~ 8
4. [단행본] - Mayersohn, M / 2002 / Modern Pharmaceutics. 4nd ed / Marcel Dekker : 23 ~ 66
5. [학술지(정기간행물)] - Amidon, G. L / 1995 / A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability / Pharm. Res 12 : 413 ~ 420
2. [학술지(정기간행물)] - Youn, Y. S. / 2006 / Improved intestinal delivery of salmon calcitonin by Lys18-amine specific PEGylation: Stability, permeability, pharmacokinetic behavior and in vivo hypocalcemic efficacy / J. Control Rel 114 : 334 ~ 342
3. [학술지(정기간행물)] - Sugawara, M. / 2005 / The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations / Eur. J. Pharm. Sci 26 : 1 ~ 8
4. [단행본] - Mayersohn, M / 2002 / Modern Pharmaceutics. 4nd ed / Marcel Dekker : 23 ~ 66
5. [학술지(정기간행물)] - Amidon, G. L / 1995 / A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability / Pharm. Res 12 : 413 ~ 420
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UCI(KEPA) : I410-ECN-0101-2014-400-002406016