지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.10
- 수록면
- 393 - 399 (7page)
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Bacillus subtilis natto producing high level of a fibrinolytic enzyme was selected and Ultra Nattokinase<SUP>ⓡ</SUP> was manufactured by fermentation and purification. It was performed the evaluation of the antithrombotic effect of Ultra Nattokinase<SUP>ⓡ</SUP> (20,000 FU/g) with rat blood plasma. The maximum aggregation (inhibition ratio) was 71% (0%), 69% (2.8%), 62% (12.7%), 16% (77.5%) and 9% (87.3%), respectively, in the order of 0, 5, 10, 50 and 100 mg/mL of Ultra Nattokinase<SUP>ⓡ</SUP> solutions. Ultra Nattokinase<SUP>ⓡ</SUP> had antithrombotic effect, which was associated with the suppression of collageninduced platelet aggregation. Ultra Nattokinase<SUP>ⓡ</SUP> in the topic of the FDP (fibrinogen degradation products) in blood coagulation tests showed a significant increasing trend. And based on the daily record of meal 39 people of ITT (what ?) group consisted with 19 people of NP (what ?) group and 20 people of PN (what ?) group except four people, two people who took vitamin K affecting the experiment and two people who took alcohol, finding to be taken Ultra Nattokinase<SUP>ⓡ</SUP> showed an increase in the FDP value after four weeks. In addition, FDP value of 41 people of ITT group except two people having metabolic syndrome was increased by Ultra Nattokinase<SUP>ⓡ</SUP>.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
References
참고문헌 (16)
참고문헌 신청
Fujita, M / 1993 / Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan / Biochem. Biophys. Res. Commun 197:1340~1347
Al Dieri R / 2004 / Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time / J. Thromb. Haemost 2:1395~1401
Chang, Y. Y / 2008 / Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds / Intern. Med 47:467~469
Omura, K / 2005 / A newly derived protein from Bacillus subtilis natto with both antithrombotic and fibrinolytic effects / J. Pharmacol. Sci 99:247~251
Omura, K / 2004 / Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis natto / Biofactors 22:185~187
Al Dieri R / 2004 / Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time / J. Thromb. Haemost 2:1395~1401
Chang, Y. Y / 2008 / Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds / Intern. Med 47:467~469
Omura, K / 2005 / A newly derived protein from Bacillus subtilis natto with both antithrombotic and fibrinolytic effects / J. Pharmacol. Sci 99:247~251
Omura, K / 2004 / Fibrinolytic and anti-thrombotic effect of NKCP, the protein layer from Bacillus subtilis natto / Biofactors 22:185~187
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UCI(KEPA) : I410-ECN-0101-2014-400-002405524