지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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It is important to begin left ventricular assist device (LVAD) treatment at appropriate time for heart failure patients who expect cardiac recovery after the therapy. In order to predict the optimal timing of LVAD implantation, we predicted pumping efficacy of LVAD according to the severity of heart failure theoretically. We used LVAD-implanted cardiovascular system model which consist of 8 Windkessel compartments for the simulation study. The time-varying compliance theory was used to simulate ventricular pumping function in the model. The ventricular systolic dysfunction was implemented by increasing the end-systolic ventricular compliance. Using the mathematical model, we predicted cardiac responses such as left ventricular peak pressure, cardiac output, ejection fraction, and stroke work according to the severity of ventricular systolic dysfunction under the treatments of continuous and pulsatile LVAD. Left ventricular peak pressure, which indicates the ventricular loading condition, decreased maximally at the 1st level heart-failure under pulsatile LVAD therapy and 2nd level heart-failure under continuous LVAD therapy. We conclude that optimal timing for pulsatile LVAD treatment is 1st level heart-failure and for continuous LVAD treatment is 2nd level heart-failure when considering LVAD treatment as "bridge to recovery".
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ABSTRACT
1. 서론
2. 방법
3. 결과
4. 토의 및 결론
REFERENCES
참고문헌 (7)
참고문헌 신청
1. [학술지(정기간행물)] - D. Casarotto / 2003 / The last to die is hope: prolonged mechanical circulatory support with a Novacor left ventricular assist device as a bridge to transplantation / J Thorac Cardiovasc Surg 125 : 417 ~ 418
2. [학술지(정기간행물)] - D. J. Goldstein / 2003 / Worldwide experience with the MicroMed DeBakey Ventricular Assist Device as a bridge to transplantation / Circulation 108 (1) : 272 ~ 277
3. [학술지(정기간행물)] - M. Schweiger / 2013 / Management of complications in long-term LVAD support / Int J Artif Organs 36 : 444 ~ 446
4. [학술지(정기간행물)] - K. M. Lim / 2009 / Computational analysis of the effect of the type of LVAD flow on coronary perfusion and ventricular afterload / J Physiol Sci 59 : 307 ~ 316
5. [학술지(정기간행물)] - K. M. Lim / 2012 / Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model / J Physiol Sci 62 : 11 ~ 19
2. [학술지(정기간행물)] - D. J. Goldstein / 2003 / Worldwide experience with the MicroMed DeBakey Ventricular Assist Device as a bridge to transplantation / Circulation 108 (1) : 272 ~ 277
3. [학술지(정기간행물)] - M. Schweiger / 2013 / Management of complications in long-term LVAD support / Int J Artif Organs 36 : 444 ~ 446
4. [학술지(정기간행물)] - K. M. Lim / 2009 / Computational analysis of the effect of the type of LVAD flow on coronary perfusion and ventricular afterload / J Physiol Sci 59 : 307 ~ 316
5. [학술지(정기간행물)] - K. M. Lim / 2012 / Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model / J Physiol Sci 62 : 11 ~ 19
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UCI(KEPA) : I410-ECN-0101-2014-580-002441134