지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study examined the effects of 8 types of herbal prescriptions prescribed to alleviate dementia symptoms in a rat model of arterial thrombosis induced by ferric chloride (FeCl₃).
Methods: Thirty minutes before 35% FeCl₃ treatment, SD rats were intraperitoneally injected with the 8 types of herbal prescriptions, respectively. We tested the effects of the herbal prescriptions on time to occlusion (TTO) in an arterial thrombosis model using a laser Doppler flow meter. In addition, thrombus weight (TW) and collagen fiber damages were evaluated in the same condition.
Results: Herbal prescriptions showed the following rank-order based on their TTO: Chong-myung-tang (CMT) > modified Jangwonhan 02 (LMK02) > Toki-shakuyaku-san (TSS) ≥Oren-gedoku-to (OGT) ≥Yokukansan (YKS). In particular, CMT (100 mg/kg, i.p.) and LMK02 (100 mg/kg, i.p.) delayed the TTO the most (14.83 ± 0.98 and 13.67 ± 1.03 min, respectively) compared with the vehicle group (7.95 ± 0.78 min, P<0.001). In addition, CMT, LMK02, and OGT treatment (0.63 ± 0.01, 0.66 ± 0.02 and 0.67 ± 0.01 mg/mm, respectively) significantly reduced thrombus weight compared with the vehicle treatment (0.78 ± 0.03, P<0.001) and also alleviated collagen fiber damage (CMT; 28.40 ± 2.22%, LMK02; 30.79 ± 4.07%, OGT; 26.20 ± 1.48%) in the vessels injured by FeCl₃. Therefore, CMT and LMK02 showed the greatest preventive activity in rat model of arterial thrombosis induced by FeCl₃.
Conclusions: These results provide experimental evidence for traditional use of herbal prescriptions, suggesting that CMT and LMK02 extracts could be used to prevent vascular injury and thrombosis in the early stages of dementia.
Methods: Thirty minutes before 35% FeCl₃ treatment, SD rats were intraperitoneally injected with the 8 types of herbal prescriptions, respectively. We tested the effects of the herbal prescriptions on time to occlusion (TTO) in an arterial thrombosis model using a laser Doppler flow meter. In addition, thrombus weight (TW) and collagen fiber damages were evaluated in the same condition.
Results: Herbal prescriptions showed the following rank-order based on their TTO: Chong-myung-tang (CMT) > modified Jangwonhan 02 (LMK02) > Toki-shakuyaku-san (TSS) ≥Oren-gedoku-to (OGT) ≥Yokukansan (YKS). In particular, CMT (100 mg/kg, i.p.) and LMK02 (100 mg/kg, i.p.) delayed the TTO the most (14.83 ± 0.98 and 13.67 ± 1.03 min, respectively) compared with the vehicle group (7.95 ± 0.78 min, P<0.001). In addition, CMT, LMK02, and OGT treatment (0.63 ± 0.01, 0.66 ± 0.02 and 0.67 ± 0.01 mg/mm, respectively) significantly reduced thrombus weight compared with the vehicle treatment (0.78 ± 0.03, P<0.001) and also alleviated collagen fiber damage (CMT; 28.40 ± 2.22%, LMK02; 30.79 ± 4.07%, OGT; 26.20 ± 1.48%) in the vessels injured by FeCl₃. Therefore, CMT and LMK02 showed the greatest preventive activity in rat model of arterial thrombosis induced by FeCl₃.
Conclusions: These results provide experimental evidence for traditional use of herbal prescriptions, suggesting that CMT and LMK02 extracts could be used to prevent vascular injury and thrombosis in the early stages of dementia.
목차
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Decarli C / 2004 / Vascular factors in dementia: anoverview / J Neurol Sci 226 (1-2) : 19 ~ 23
2. [학술지(정기간행물)] - Duron E / 2008 / Vascular risk factors,cognitive decline, and dementia / Vasc HealthRisk Manag 4 (2) : 363 ~ 381
3. [학술지(정기간행물)] - Quintanilla RA / 2012 / Understanding Risk Factors for Alzheimer'sDisease: Interplay of Neuroinflammation,Connexin-based Communication and OxidativeStress / Arch Med Res 43 (8) : 632 ~ 644
4. [학술지(정기간행물)] - Marchesi VT / 2011 / Alzheimer’s dementia begins as adisease of small blood vessels, damaged byoxidative-induced inflammation anddysregulated amyloid metabolism: implicationsfor early detection and therapy / FASEB J 25 (1) : 5 ~ 13
5. [학술지(정기간행물)] - Gorelick PB / 2011 / Vascularcontributions to cognitive impairment anddementia: a statement for healthcareprofessionals from the American HeartAssociation/American Stroke Association / troke 42 (9) : 2672 ~ 2713
2. [학술지(정기간행물)] - Duron E / 2008 / Vascular risk factors,cognitive decline, and dementia / Vasc HealthRisk Manag 4 (2) : 363 ~ 381
3. [학술지(정기간행물)] - Quintanilla RA / 2012 / Understanding Risk Factors for Alzheimer'sDisease: Interplay of Neuroinflammation,Connexin-based Communication and OxidativeStress / Arch Med Res 43 (8) : 632 ~ 644
4. [학술지(정기간행물)] - Marchesi VT / 2011 / Alzheimer’s dementia begins as adisease of small blood vessels, damaged byoxidative-induced inflammation anddysregulated amyloid metabolism: implicationsfor early detection and therapy / FASEB J 25 (1) : 5 ~ 13
5. [학술지(정기간행물)] - Gorelick PB / 2011 / Vascularcontributions to cognitive impairment anddementia: a statement for healthcareprofessionals from the American HeartAssociation/American Stroke Association / troke 42 (9) : 2672 ~ 2713
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UCI(KEPA) : I410-ECN-0101-2014-510-002924676