지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.7
- 수록면
- 315 - 323 (9page)
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초록· 키워드
오류제보하기
Ginseng is known to have antistress effects. Previously, red ginseng (RG) was shown to repress stress-induced peptidyl arginine deiminase type IV (PADI4) via estrogen receptor β (ERβ) in the brain, thus inhibiting brain cell apoptosis. Moreover, tumor necrosis factor (TNF)-α plays a critical role in immobilization (IMO) stress. However, the signaling pathway of RG-mediated repressesion of inflammation is not completely understood. In this study, we determined how RG modulated gene expression in stressed brain cells. Since secretion of TNF-α is modulated via TNF-α converting enzyme (TACE) and nuclear factor (NF)-κB, we examined the inflammatory pathway in stressed brain cells. Immunohistochemistry revealed that TACE was induced by IMO stress, but RG repressed TACE induction. Moreover, PADI4 siRNA repressed TACE expression compared to the mock transfected control suggesting that PADI4 was required for TACE expression. A reporter assay also revealed that H₂O₂ oxidative stress induced NF-κB in neuroblastoma SK-N-SH cells, however, RG pretreatment repressed NF-κB induction. These findings were supported by significant induction of nitric oxide and reactive oxygen species (ROS) by oxidative stress, which could be repressed by RG administration. Taken together, RG appeared to repress stress-induced PADI4 via TACE and NF-κB in brain cells thus preventing production of ROS and subsequently protecting brain cells from apoptosis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
1. [학술지(정기간행물)] - Bhattacharya SK / 2003 / Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress / Pharmacol Biochem Behav 75 : 547 ~ 555
2. [학술지(정기간행물)] - Kaneko H / 2004 / Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its anti-stress action for prevention of disease / J Pharmacol Sci 95 : 158 ~ 162
3. [학술지(정기간행물)] - Lee SH / 2006 / The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress / Pharmacol Res 54 : 46 ~ 49
4. [학술지(정기간행물)] - Kim YC / 1998 / Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration / J Neurosci Res 53 : 426 ~ 432
5. [학술지(정기간행물)] - Radad K / 2004 / Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate / Brain Res 1021 : 41 ~ 53
2. [학술지(정기간행물)] - Kaneko H / 2004 / Proof of the mysterious efficacy of ginseng: basic and clinical trials: clinical effects of medical ginseng, Korean red ginseng: specifically, its anti-stress action for prevention of disease / J Pharmacol Sci 95 : 158 ~ 162
3. [학술지(정기간행물)] - Lee SH / 2006 / The antistress effect of ginseng total saponin and ginsenoside Rg3 and Rb1 evaluated by brain polyamine level under immobilization stress / Pharmacol Res 54 : 46 ~ 49
4. [학술지(정기간행물)] - Kim YC / 1998 / Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration / J Neurosci Res 53 : 426 ~ 432
5. [학술지(정기간행물)] - Radad K / 2004 / Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate / Brain Res 1021 : 41 ~ 53
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UCI(KEPA) : I410-ECN-0101-2014-520-002962163