지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.7
- 수록면
- 300 - 307 (8page)
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초록· 키워드
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20S-dihydroprotopanaxatriol (2H-PPT) is a derivative of protopanaxatrol from ginseng. Unlike other components from Panax ginseng, the pharmacological activity of this compound has not been fully elucidated. In this study, we investigated the modulatory activity of 2H-PPT on the cellular responses of monocytes and macrophages to understand its immunoregulatory actions. 2H-PPT strongly upregulated the release of radicals in sodium nitroprusside-treated RAW264.7 cells and the surface levels of costimulatory molecule CD86. More importantly, this compound remarkably suppressed nitric oxide production, morphological changes, phagocytic uptake, cell-cell aggregation, and cell-matrix adhesion in RAW264.7 and U937 cells in the presence or absence of lipopolysaccharide, anti-CD43 antibody, fibronectin, and phorbal 12-myristate 13-acetate. Therefore, our results suggest that 2H-PPT can be applied as a novel functional immunoregulator of macrophages and monocytes.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Lee YG / 2011 / Functional role of Akt in macrophage-mediated innate immunity / Front Biosci 16 : 517 ~ 530
2. [학술지(정기간행물)] - Yu T / 2012 / The pivotal role of TBK1 in inflammatory responses mediated by macrophages / Mediators Inflamm 2012 : 979105 ~
3. [학술지(정기간행물)] - Byeon SE / 2012 / The role of Src kinase in macrophage-mediated inflammatory responses / Mediators Inflamm 2012 : 512926 ~
4. [학술지(정기간행물)] - Jeannin P / 2011 / IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-gamma / Immunotherapy 3 (4 Suppl) : 23 ~ 26
5. [학술지(정기간행물)] - Hasani-Ranjbar S / 2009 / A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity / World J Gastroenterol 15 : 3073 ~ 3085
2. [학술지(정기간행물)] - Yu T / 2012 / The pivotal role of TBK1 in inflammatory responses mediated by macrophages / Mediators Inflamm 2012 : 979105 ~
3. [학술지(정기간행물)] - Byeon SE / 2012 / The role of Src kinase in macrophage-mediated inflammatory responses / Mediators Inflamm 2012 : 512926 ~
4. [학술지(정기간행물)] - Jeannin P / 2011 / IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-gamma / Immunotherapy 3 (4 Suppl) : 23 ~ 26
5. [학술지(정기간행물)] - Hasani-Ranjbar S / 2009 / A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity / World J Gastroenterol 15 : 3073 ~ 3085
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UCI(KEPA) : I410-ECN-0101-2014-520-002962143