지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.7
- 수록면
- 283 - 292 (10page)
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초록· 키워드
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Ginsenosides are divided into two groups based on the types of the panaxadiol group (e.g., ginsenoside-Rb1 and -Rc) and the panaxatriol group (e.g., ginsenoside-Rg1 and -Re). Among them, ginsenoside-Re (G-Re) is one of the compounds with the highest content in Panax ginseng and is responsible for pharmacological effects. However, it is not yet well reported if G-Re increases the hemodynamics functions on ischemia (30 min)/reperfusion (120 min) (I/R) induction. Therefore, in the present study, we investigated whether treatment of G-Re facilitated the recovery of hemodynamic parameters (heart rate, perfusion pressure, aortic flow, coronary flow, and cardiac output) and left ventricular developed pressure (±dp/dt<SUB>max</SUB>). This research is designed to study the effects of G-Re by studying electrocardiographic changes such as QRS interval, QT interval and R-R interval, and inflammatory marker such as tissue necrosis factor-α (TNF-α) in heart tissue in I/R-induced heart. From the results, I/R induction gave a significant increase in QRS interval, QT interval and R-R interval, but showed decrease in all hemodynamic parameters. I/R induction resulted in increased TNF-α level. Treatment of G-Re at 30 and 100 μM doses before I/R induction significantly prevented the decrease in hemodynamic parameters, ameliorated the electrocardiographic abnormality, and inhibited TNF-α level. In this study, G-Re at 100 μM dose exerted more beneficial effects on cardiac function and preservation of myocardium in I/R injury than 30 μM. Collectively, these results indicate that G-Re has distinct cardioprotectective effects in I/R induced rat heart.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Ostadal B. / 2009 / The past, the present and the future of experimental research on myocardial ischemia and protection / Pharmacol Rep 61 : 3 ~ 12
2. [학술지(정기간행물)] - Gross GJ / 1999 / Mechanisms of postischemic contractile dysfunction / Ann Thorac Surg 68 : 1898 ~ 1904
3. [학술지(정기간행물)] - Piper HM / 1999 / Prime causes of rapid cardiomyocyte death during reperfusion / Ann Thorac Surg 68 : 1913 ~ 1919
4. [학술지(정기간행물)] - Verma S / 2002 / Fundamentals of reperfusion injury for the clinical cardiologist / Circulation 105 : 2332 ~ 2336
5. [단행본] - Fleming PR. / 1997 / A short history of cardiology / Rodopi Publishers
2. [학술지(정기간행물)] - Gross GJ / 1999 / Mechanisms of postischemic contractile dysfunction / Ann Thorac Surg 68 : 1898 ~ 1904
3. [학술지(정기간행물)] - Piper HM / 1999 / Prime causes of rapid cardiomyocyte death during reperfusion / Ann Thorac Surg 68 : 1913 ~ 1919
4. [학술지(정기간행물)] - Verma S / 2002 / Fundamentals of reperfusion injury for the clinical cardiologist / Circulation 105 : 2332 ~ 2336
5. [단행본] - Fleming PR. / 1997 / A short history of cardiology / Rodopi Publishers
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UCI(KEPA) : I410-ECN-0101-2014-520-002962123