지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 1,223 - 1,233 (11page)
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The purpose of this study was to investigate the effects of aerobic exercise training and quercetin supplementation with low fat diet on inflammation and Th1, Th2 cytokine production in splenocytes in obese mice. C57BL/6 mice were fed high fat diet (45% fat) for 12 weeks first, then switched low fat diet (10% fat) for 8 weeks. Mice were divided into four groups: (1) control group (HLC, n=10), (2) quercetin with low fat diet (HLQ), (3) exercise with low fat diet (HLE), and (4) quercetin and exercise with low fat diet (HLEQ). Exercise training was performed for 8 weeks on a motorized treadmill running for 30~60 min/day at 10~18 m/min, 0% grade, five times per week. Quercetin supplement was administrated once a day, 10mg/kg, 5 days/week for 8 weeks. After 20 weeks, all the splenocyte was collected and Con A(Concanvalin A 10μg/㎖) were used to stimulate the cells. Then, TNF-a, IL-1β, IL-6, IL-2, IFN-γ, IL-4, IL-10 were measured by ELISA kits. Two way ANOVA was used and p value under 0.05 was considered as statistical significance. In the results, body weight, TNF-a production were significantly reduced and IL-2, IL=10 were significantly increased after 8 weeks aerobic exercise with low fat diet. This data suggest that aerobic exercise training with low fat diet has a positive effect to improve immunocompetence in obese mice
목차
Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
참고문헌
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - Adamopoulos, S. / 2002 / Physical training modulates proinflammatory cytokines and the soluble fas/soluble fas ligand system in patients with chronic heart failure / J. Am. Coll. Cardiol 39 : 653 ~ 663
2. [학술지(정기간행물)] - Alf, L. / 2001 / Effects of aerobic exercise training on plasma levels of tumor necrosis factor-a in patients with heart failure / J. Am. Coll. Cardio 88 : 805 ~ 808
3. [학술지(정기간행물)] - Amar, S. / 2007 / Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge / PNAS 104 : 20466 ~ 20471
4. [학술지(정기간행물)] - Basile, A. / 2000 / Antibacterial and allelopathic activity of extract from Castanea sativa leaves / Fitoterapia 71 : 110 ~ 116
5. [학술지(정기간행물)] - Bradley, R. L. / 2008 / Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice / Am. J. Physio. Endocrinol. Metab 295 : 586 ~ 594
2. [학술지(정기간행물)] - Alf, L. / 2001 / Effects of aerobic exercise training on plasma levels of tumor necrosis factor-a in patients with heart failure / J. Am. Coll. Cardio 88 : 805 ~ 808
3. [학술지(정기간행물)] - Amar, S. / 2007 / Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge / PNAS 104 : 20466 ~ 20471
4. [학술지(정기간행물)] - Basile, A. / 2000 / Antibacterial and allelopathic activity of extract from Castanea sativa leaves / Fitoterapia 71 : 110 ~ 116
5. [학술지(정기간행물)] - Bradley, R. L. / 2008 / Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice / Am. J. Physio. Endocrinol. Metab 295 : 586 ~ 594
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UCI(KEPA) : I410-ECN-0101-2014-690-003230570