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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 158 - 163 (6page)
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초록· 키워드
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Cholestatic liver is associated with hepatic inflammation and elevated proinflammatory cytokines. Recent studies indicate that certain cytokines can modulate bile secretion. In the present study, we have examined the role of interleukin (IL-2) on the bile secretion by a combination of study models. To examine the relevance of IL-2 on bile secretion, the expression of IL-2 and IL-2 receptor (IL-2R) of isolated normal and bile duct ligated (BDL) rats cholangiocytes was first measured by RT-PCR. In BDL rats, the expression of IL-2 and IL-2R was significantly increased compared with normal rats. To study the effect of IL-2 on bile secretion, bile flow was measured in normal and BDL rats. At the level of cholangiocytes, secretory responses of isolated bile duct unit (IBDU)s were quantified by videomicroscopy. The administrations of IL-2 had no significant effect on basal bile secretion in normal and BDL rats. There was no significant effect of IL-2 on basal bile ductular secretion as evidenced by no significant difference in luminal area of the IBDUs perfusedwith 100 pM of IL-2 from those of albumin carrier control. However, the secretin-stimulated bile ductular secretion was significantly (P ＜ 0.01) inhibited by 34 ± 4% (normal, n = 12), 21 ± 5.3% (BDL 2 wk, n = 12) and 15 ± 5.2% (BDL 4 wk, n = 12) with the co-administration of IL-2. As with other cytokines, physiologically relevant concentration of IL-2 can significantly inhibit secretin-stimulated bile ductular secretion. These findings support the important roles of cytokines in modulating bile secretion and may contribute to the cholestasis seen in cholestatic liver diseases.
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참고문헌 (32)
참고문헌 신청
1. [학술지(정기간행물)] - Alpini G / 1989 / Bile secretory function of intrahepatic biliary epithelium in the rat / Am J Physiol Gastrointest Liver Physiol 257 : G124 ~ G133
2. [학술대회논문] - Beadling C / 1993 / Isolation of interleukin 2-induced immediate-early genes / Proc Natl Acad Sci U S A 90 : 2719 ~ 2723
3. [학술지(정기간행물)] - Braunstein GM / 2001 / Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation / J Biol Chem 276 : 6621 ~ 6630
4. [학술지(정기간행물)] - Cantrell DA / 1984 / The interleukin-2 T-cell system: a new cell growth model / Science 224 : 1312 ~ 1316
5. [학술지(정기간행물)] - Cho WK / 2001 / Isolation of functional polarized bile duct units from mouse liver / Am J Physiol Gastrointest Liver Physiol 280 : G241 ~ G246
2. [학술대회논문] - Beadling C / 1993 / Isolation of interleukin 2-induced immediate-early genes / Proc Natl Acad Sci U S A 90 : 2719 ~ 2723
3. [학술지(정기간행물)] - Braunstein GM / 2001 / Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation / J Biol Chem 276 : 6621 ~ 6630
4. [학술지(정기간행물)] - Cantrell DA / 1984 / The interleukin-2 T-cell system: a new cell growth model / Science 224 : 1312 ~ 1316
5. [학술지(정기간행물)] - Cho WK / 2001 / Isolation of functional polarized bile duct units from mouse liver / Am J Physiol Gastrointest Liver Physiol 280 : G241 ~ G246
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UCI(KEPA) : I410-ECN-0101-2014-500-003262988