지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Radiation is one of the major therapy for the removal of cancer cells. The results of the radiation therapy depend on the radio-resistance of cancer cells. For the effective treatment in these radio-resistant cancers, the use of chemicals that act on cancer cells is known to enhance the cytotoxic effects of radiation therapy. In this study, I investigated the effect of potassium cyanate (KCN) on the irradiated-colorectal cancer cell line, HCT 116 cells. KCN induces the carbamylation of proteins and can change the biological activity of various human cells. To understand the effect of KCN on the radiosensitivity of HCT 116 cells, I examined alteration of the cell cycle, generation of reactive oxygen species (ROS), cell viability, apoptosis and intracellular signaling proteins in the irradiated cells with/without KCN treatment. Combination treatment caused significant increase in sub G0/G1 and ROS generation in HCT 116 cells. KCN inhibited the proliferation and cell viability in irradiated HCT 116 cells. KCN-induced apoptosis of irradiated cells was processed via the activation of caspase 3 and caspase 9. Apoptosis-associated signal proteins, including Bax and Bcl-2 were regulated by irradiation with KCN treatment. Taken together, these results may indicate that KCN enhances the radiosensitivity of radio-resistant cell and then has a synergistic effect on radiation therapy in colorectal cancer.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (15)
참고문헌 신청
Apostolov EO / 2011 / Endonuclease G mediates endothelial cell death induced by carbamylated LDL / Am J Physiol Heart Circ Physiol 300:H1997~H2004
Blumberg D / 2002 / Treatment of colon and rectal cancer / J Clin Gastro Enterol 34:15~26
Bouzourene H / 2002 / Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy / Cancer 94:1121~1130
Fluckiger R / 1981 / Hemoglobin carbamylation in uremia / N Engl J Med 304:823~827
Gross A / 1999 / Bcl-2 family members and the mitochondria in apoptosis / Genes Dev 13:1899~1911
Blumberg D / 2002 / Treatment of colon and rectal cancer / J Clin Gastro Enterol 34:15~26
Bouzourene H / 2002 / Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy / Cancer 94:1121~1130
Fluckiger R / 1981 / Hemoglobin carbamylation in uremia / N Engl J Med 304:823~827
Gross A / 1999 / Bcl-2 family members and the mitochondria in apoptosis / Genes Dev 13:1899~1911
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UCI(KEPA) : I410-ECN-0101-2014-500-003262897