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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.18 No.2
- 발행연도
- 2013.6
- 수록면
- 124 - 132 (9page)
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In this study, novel peptides (NIPP-1, NIPP-2) derived from Navicula incerta (microalgae) protein hydrolysate were explored for their inhibitory effects on collagen release in hepatic fibrosis with the investigation of its underlying mechanism of action. TGF-β1 activated fibrosis in LX-2 cells was examined in the presence or absence of purified peptides NIPP-1 and NIPP-2. Besides the mechanisms of liver cell injury, protective effects of NIPP-1 and NIPP-2 were studied to show the protective mechanism against TGF-β1 stimulated fibrogenesis. Our results showed that the core protein of NIPP-1 peptide prevented fibril formation of type I collagen, elevated the MMP level and inhibited TIMP production in a dose-dependent manner. The treatment of NIPP-1 and NIPP-2 on TGF-β1 induced LX-2 cells alleviated hepatic fibrosis. Moreover, α-SMA, TIMPs, collagen and PDGF in the NIPP-1 treated groups were significantly decreased. Therefore, it could be suggested that NIPP-1 has potential to be used in anti-fibrosis treatment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - Friedman SL / 2000 / Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury / J Biol Chem 275 : 2247 ~ 2250
2. [학술지(정기간행물)] - Czochra P / 2006 / Liver fibrosis induced by hepatic overexpression of PDGF-b in transgenic mice / J Hepatol 45 : 419 ~ 428
3. [학술지(정기간행물)] - Felver ME / 1990 / Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis / Alcohol Clin Exp Res 14 : 255 ~ 259
4. [학술지(정기간행물)] - Friedman SL / 1993 / The cellular basis of hepatic fibrosis− Mechanisms and treatment strategies / N Engl J Med 328 : 1828 ~ 1835
5. [학술지(정기간행물)] - Bataller R / 2001 / Hepatic stellate cells as a target for the treatment of liver fibrosis / Semin Liver Dis 21 : 437 ~ 451
2. [학술지(정기간행물)] - Czochra P / 2006 / Liver fibrosis induced by hepatic overexpression of PDGF-b in transgenic mice / J Hepatol 45 : 419 ~ 428
3. [학술지(정기간행물)] - Felver ME / 1990 / Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis / Alcohol Clin Exp Res 14 : 255 ~ 259
4. [학술지(정기간행물)] - Friedman SL / 1993 / The cellular basis of hepatic fibrosis− Mechanisms and treatment strategies / N Engl J Med 328 : 1828 ~ 1835
5. [학술지(정기간행물)] - Bataller R / 2001 / Hepatic stellate cells as a target for the treatment of liver fibrosis / Semin Liver Dis 21 : 437 ~ 451
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UCI(KEPA) : I410-ECN-0101-2014-510-003288066