지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 121 - 127 (7page)
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초록· 키워드
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Nanotoxicological research has shown toxicity of nanomaterials to be inversely related to particle size. However, the contribution of agglomeration to the toxicity of nanomaterials has not been sufficiently studied, although it is known that agglomeration is associated with increased nanomaterial size. In this study, we prepared aerosols of nano-sized carbon black by 2 different ways to verify the effects of agglomeration on the toxicity and deposition of nano-sized carbon black. The 2 methods of preparation included the carbon black dispersion method that facilitated clustering without sonication and the carbon black dispersion method involving sonication to achieve scattering and deagglomeration. Male Sprague-Dawley rats were exposed to carbon black aerosols 6 hr a day for 3 days or for 2 weeks. The median mass aerodynamic diameter of carbon black aerosols averaged 2.08 μm (for aerosol prepared without sonication; group N) and 1.79 μm (for aerosol prepared without sonication; group S). The average concentration of carbon black during the exposure period for group N and group S was 13.08 ± 3.18 mg/m³ and 13.67 ± 3.54 mg/m³, respectively, in the 3-day experiment. The average concentration during the 2-week experiment was 9.83 ± 3.42 mg/m³ and 9.08 ± 4.49 mg/m³ for group N and group S, respectively. The amount of carbon black deposition in the lungs was significantly higher in group S than in group N in both 3-day and 2-week experiments. The number of total cells, macrophages and polymorphonuclear leukocytes in the bronchoalveolar lavage (BAL) fluid, and the number of total white blood cells and neutrophils in the blood in the 2-week experiment were significantly higher in group S than in normal control. However, differences were not found in the inflammatory cytokine levels (IL-1β, TNF-α, IL-6, etc.) and protein indicators of cell damage (albumin and lactate dehydrogenase) in the BAL fluid of both group N and group S as compared to the normal control. In conclusion, carbon black aerosol generated by sonication possesses smaller nanoparticles that are deposited to a greater extent in the lungs than is aerosol formulated without sonication. Additionally, rats were narrowly more affected when exposed to carbon black aerosol generated by sonication as compared to that produced without sonication.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
REFERENCES
참고문헌 (19)
참고문헌 신청
NSET. / 2011 / The National nanotechnology Initiative. Research and Development Leading to a Revolution in Technology and Industry Supplement to the Present’s FY 2011 Budget / Subcommittee on nanoscale Science, Engineering and Technology, Committee on Technology, National Science and Technology Council, Washington, DC :1~65
Ferin, J. / 1990 / Increased pulmonary toxicity of ultrafine particles 1. Particle clearance, translocation, morphology / J. Aerosol Sci 21:381~384
Oberdorster, G. / 1990 / Increased pulmonary toxicity of ultrafine particles. 2. Lung lavage studies / J. Aerosol Sci. 21:384~387
Maynard, A. D. / 2011 / The new toxicology of sophisticated materials: Nanotoxicology and beyond / Toxicol. Sci. 120:S109~S129
Madl, A.K. / 2009 / Health effects of inhaled engineered and incidental nanoparticles / Crit. Rev. Toxicol. 39:629~658
Ferin, J. / 1990 / Increased pulmonary toxicity of ultrafine particles 1. Particle clearance, translocation, morphology / J. Aerosol Sci 21:381~384
Oberdorster, G. / 1990 / Increased pulmonary toxicity of ultrafine particles. 2. Lung lavage studies / J. Aerosol Sci. 21:384~387
Maynard, A. D. / 2011 / The new toxicology of sophisticated materials: Nanotoxicology and beyond / Toxicol. Sci. 120:S109~S129
Madl, A.K. / 2009 / Health effects of inhaled engineered and incidental nanoparticles / Crit. Rev. Toxicol. 39:629~658
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UCI(KEPA) : I410-ECN-0101-2014-510-003293241