지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 99 - 106 (8page)
이용수
초록· 키워드
오류제보하기
Clostridium difficile infection (CDI) has become a significant threat to public health. Although broad-spectrum antibiotic therapy is the primary treatment option for CDI, its use has evident limitations. Probiotics have been proved to be effective in the treatment of CDI and are a promising therapeutic option for CDI. In this study, 4 strains of lactic acid bacteria (LAB), namely, Lactobacillus rhamnosus (LR5), Lactococcuslactis (SL3), Bifidobacterium breve (BR3), and Bifidobacterium lactis (BL3) were evaluated for their anti-C. difficile activity. Co-culture incubation of C. difficile (10<SUP>6</SUP> and 10<SUP>10</SUP> CFU/ml) with each strain of LAB indicated that SL3 possessed the highest antimicrobial activity over a 24-hr period. The cell-free supernatants of the 4 LAB strains exhibited MIC<SUB>50</SUB> values between 0.424 mg/ml (SL3) and 1.318 (BR3) mg/ml. These results may provide a basis for alternative therapies for the treatment of C. difficile-associated gut disorders.
목차
INTRODUCTION
MATERIAL AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
Aslam, S. / 2005 / Treatment of Clostridium difficile-associated disease: old therapies and new strategies / Lancet Infect. Dis. 5:549~557
Nelson, R. / 2007 / Antibiotic treatment for Clostridium difficile- associated diarrhea in adults / Cochrane Database Syst. Rev. 18:CD004610
Bartlett, J. G. / 2010 / Clostridium difficile: progress and challenges / Ann. N. Y. Acad. Sci. 1213:62~69
Ohl, M. E. / 2005 / What are effective therapies for Clostridium difficile-associated diarrhea? / J. Fam. Pract. 54:176~178
Dethlefsen, L. / 2008 / The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing / PLoS Biol. 6:e280
Nelson, R. / 2007 / Antibiotic treatment for Clostridium difficile- associated diarrhea in adults / Cochrane Database Syst. Rev. 18:CD004610
Bartlett, J. G. / 2010 / Clostridium difficile: progress and challenges / Ann. N. Y. Acad. Sci. 1213:62~69
Ohl, M. E. / 2005 / What are effective therapies for Clostridium difficile-associated diarrhea? / J. Fam. Pract. 54:176~178
Dethlefsen, L. / 2008 / The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing / PLoS Biol. 6:e280
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2014-510-003293216