Comparative Efficacy of Ivermectin and Levamisole for Reduction of Migrating and Encapsulated Larvae of Baylisascaris transfuga in Mice

Yan Fu; Hua-Ming Nie; Li-Li Niu; Yue Xie; Jia-Bo Deng; Qiang Wang; Guang-You Yang; Xiao-Bin Gu; Shu-Xian Wang

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자료유형: 학술저널

저자정보: Yan Fu (Sichuan Agricultural University) Hua-Ming Nie (Sichuan Agricultural University) Li-Li Niu (Chengdu Zoological Garden) Yue Xie (Sichuan Agricultural University) Jia-Bo Deng (Chengdu Zoological Garden) Qiang Wang (Chengdu Zoological Garden) Guang-You Yang (Sichuan Agricultural University) Xiao-Bin Gu (Sichuan Agricultural University) Shu-Xian Wang (Sichuan Agricultural University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.49 No.2

발행연도: 2011.6

수록면: 145 - 151 (7page)

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The comparative efficacy of 2 anthelmintics (ivermectin and levamisole) against Baylisascaris transfuga migrating and encapsulated larvae was studied in mice. A total of 60 BALB/c mice inoculated each with about 1,000 embryonated B. transfuga eggs were equally divided into 6 groups (A-F) randomly. Mice of groups A and B were treated with ivermectin and levamisole, respectively, on day 3 post-infection (PI). Mice of groups A-C were killed on day 13 PI. Similarly, groups D and E were treated with ivermectin and levamisole, respectively, on day 14 PI, and all mice of groups D-F were treated on day 24 PI. The groups C and F were controls. Microexamination was conducted to count the larvae recovering from each mouse. The percentages of reduction in the number of migrating larvae recovered from group A (ivermectin) and B (levamisole) were 88.3% and 81.1%, respectively. In addition, the reduction in encapsulated larvae counts achieved by ivermectin (group D) and levamisole (group E) was 75.0% and 49.2%, respectively. The results suggested that, to a certain extent, both anthelmintics appeared to be more effective against migrating larvae than encapsulated larvae. However, in the incipient stage of infection, ivermectin may be more competent than levamisole as a larvicidal drug for B. transfuga.

#Baylisascaris transfuga #ivermectin #levamisole #migrating larvae #encapsulated larvae #granuloma

참고문헌 (22)

참고문헌 신청

1. [학술지(정기간행물)] - Papini R / 1994 / A report on the pathology of Baylisascaris transfuga (Ascarididae: Nematoda) for mice / Rev Med Vet 145 : 949 ~ 952

2. [학술지(정기간행물)] - Sprent JF / 1964 / Observations relating to the diagnosis of visceral larval migrans / In Corradetti A ed, Proc First Int Congr Parasitol 2 : 802 ~ 803

3. [학술지(정기간행물)] - Papini R / 1995 / Parenteral infection in mice with Baylisascaris transfuga (Nematoda: Ascaridae) infective eggs / Folia Parasitol 42 : 69 ~ 71

4. [단행본] - Kazacos KR / 2001 / Baylisascaris procyonis and related species. In Samuel WM, Kocan AA, Pybus MJ ed, Parasitic Diseases of Wild Mammals. 2nd ed / Ames, Iowa, USA. Iowa State University : 301 ~ 364

5. [학술지(정기간행물)] - Papini R / 1993 / Experimental infection in chickens with larvae of Baylisascaris transfuga (Nematoda: Ascaridae) / Folia Parasitol 40 : 141 ~ 143