지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 125 - 131 (7page)
이용수
초록· 키워드
오류제보하기
The use of sulfadoxine and pyrimethamine (SP) for treatment of vivax malaria is uncommon in most malarious areas, but Plasmodium vivax isolates are exposed to SP because of mixed infections with other Plasmodium species. As P. vivax is the most prevalent species of human malaria parasites in Iran, monitoring of resistance of the parasite against the drug is necessary. In the present study, 50 blood samples of symptomatic patients were collected from 4 separated geographical regions of south-east Iran. Point mutations at residues 57, 58, 61, and 117 were detected by the PCR-RFLP method. Polymorphism at positions 58R, 117N, and 117T of P. vivax dihydrofolate reductase (Pvdhfr) gene has been found in 12%, 34%, and 2% of isolates, respectively. Mutation at residues F57 and T61 was not detected. Five distinct haplotypes of the Pvdhfr gene were demonstrated. The 2 most prevalent haplotypes were F57S58T61S117 (62%) and F57S58T61N117 (24%). Haplotypes with 3 and 4 point mutations were not found. The present study suggested that P. vivax in Iran is under the pressure of SP and the sensitivity level of the parasite to SP is diminishing and this fact must be considered in development of malaria control programs.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Mendis K / 2001 / Carter R. The neglected burden of Plasmodium vivax malaria / Am J Trop Med Hyg 64 : 97 ~ 106
2. [학술지(정기간행물)] - Schousboe ML / 2007 / Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka / Malar J 6 : 28 ~
3. [학술지(정기간행물)] - Auliff A / 2006 / Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs / Am J Trop Med Hyg 75 : 617 ~ 621
4. [학술지(정기간행물)] - Kaur S / 2006 / Plasmodium vivax dihydrofolate reductase point mutations from the Indian subcontinent / Acta Trop 97 : 174 ~ 180
5. [학술지(정기간행물)] - Pukrittayakamee S / 2004 / Therapeutic responses to antimalarial and antibacterial drugs in vivax malaria / Acta Trop 89 : 351 ~ 356
2. [학술지(정기간행물)] - Schousboe ML / 2007 / Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka / Malar J 6 : 28 ~
3. [학술지(정기간행물)] - Auliff A / 2006 / Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs / Am J Trop Med Hyg 75 : 617 ~ 621
4. [학술지(정기간행물)] - Kaur S / 2006 / Plasmodium vivax dihydrofolate reductase point mutations from the Indian subcontinent / Acta Trop 97 : 174 ~ 180
5. [학술지(정기간행물)] - Pukrittayakamee S / 2004 / Therapeutic responses to antimalarial and antibacterial drugs in vivax malaria / Acta Trop 89 : 351 ~ 356
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UCI(KEPA) : I410-ECN-0101-2014-510-002511560