지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 235 - 243 (9page)
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초록· 키워드
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In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2 responses in T. spiralis-infected PAR2 knockout (KO) mice. The levels of the Th2 cell-secreted cytokines, IL-4, IL-5, and IL-13 were markedly reduced in the PAR2 KO mice as compared to the wild type mice following infection with T. spiralis. The serum levels of parasite-specific IgE increased significantly in the wild type mice as the result of T. spiralis infection, but this level was not significantly increased in PAR2 KO mice. The expression level of thymic stromal lymphopoietin, IL-25, and eotaxin gene (the genes were recently known as Th2 response initiators) of mouse intestinal epithelial cells were increased as the result of treatment with T. spiralis excretory-secretory proteins. However, the expression of these chemokine genes was inhibited by protease inhibitor treatments. In conclusion, PAR2 might involve in Th2 responses against T. spiralis infection.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Devlin MG / 2007 / Initial support for the hypothesis that PAR2 is involved in the immune response to Nippostrongylus brasiliensis in mice / Parasitol Res 101 : 105 ~ 109
2. [학술지(정기간행물)] - Kapsenberg ML / 2003 / Dendritic-cell control of pathogen-driven T-cell polarization / Nat Rev Immunol 3 : 984 ~ 993
3. [학술지(정기간행물)] - McKerrow JH / 2006 / Proteases in parasitic diseases / Annu Rev Pathol 1 : 497 ~ 536
4. [학술지(정기간행물)] - Ghaemmaghami AM / 2002 / The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level / Clin Exp Allergy 32 : 1468 ~ 1475
5. [학술지(정기간행물)] - Tovey ER / 1981 / Mite faeces are a major source of house dust allergens / Nature 289 : 592 ~ 593
2. [학술지(정기간행물)] - Kapsenberg ML / 2003 / Dendritic-cell control of pathogen-driven T-cell polarization / Nat Rev Immunol 3 : 984 ~ 993
3. [학술지(정기간행물)] - McKerrow JH / 2006 / Proteases in parasitic diseases / Annu Rev Pathol 1 : 497 ~ 536
4. [학술지(정기간행물)] - Ghaemmaghami AM / 2002 / The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias determined at the dendritic cell level / Clin Exp Allergy 32 : 1468 ~ 1475
5. [학술지(정기간행물)] - Tovey ER / 1981 / Mite faeces are a major source of house dust allergens / Nature 289 : 592 ~ 593
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UCI(KEPA) : I410-ECN-0101-2014-510-002511353