지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 431 - 436 (6page)
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초록· 키워드
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The onset, severity, and ultimate outcome of malaria infection are influenced by parasite-expressed virulence factors as well as by individual host responses to these determinants. In both humans and mice, liver injury follows parasite entry, persisting to the erythrocytic stage in the case of infection with the fatal strain of Plasmodium falciparum. Hepatic nuclear factor (HNF)-1α is a master regulator of not only the liver damage and adaptive responses but also diverse metabolic functions. In this study, we analyzed the expression of host HNF-1α in relation to malaria infection and evaluated its interaction with the 5´-untranslated region of subtilisin-like protease 2 (subtilase, Sub2). Recombinant human HNF-1α expressed by a lentiviral vector (LV HNF-1α) was introduced into mice. Interestingly, differences in the activity of the 5´-untranslated region of the Pf-Sub2 promoter were detected in 293T cells, and LV HNF-1α was observed to influence promoter activity, suggesting that host HNF-1α interacts with the Sub2 gene.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Kooij TW / 2006 / Plasmodium post-genomics: better the bug you know / Nat Rev Microbiol 4 : 344 ~ 357
2. [학술지(정기간행물)] - Fortin A / 2002 / Complex genetic control of susceptibility to malaria in mice / Genes Immun 3 : 177 ~ 186
3. [학술지(정기간행물)] - Griffith JW / 2007 / Goldstein DR, Bucala R. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host / J Infect Dis 196 : 1553 ~ 1564
4. [학술지(정기간행물)] - Millington OR / 2007 / Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells / PLoS Pathog 3 : 1380 ~ 1387
5. [학술지(정기간행물)] - Min-Oo G / 2007 / Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus / J Exp Med 204 : 511 ~ 524
2. [학술지(정기간행물)] - Fortin A / 2002 / Complex genetic control of susceptibility to malaria in mice / Genes Immun 3 : 177 ~ 186
3. [학술지(정기간행물)] - Griffith JW / 2007 / Goldstein DR, Bucala R. Toll-like receptor modulation of murine cerebral malaria is dependent on the genetic background of the host / J Infect Dis 196 : 1553 ~ 1564
4. [학술지(정기간행물)] - Millington OR / 2007 / Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells / PLoS Pathog 3 : 1380 ~ 1387
5. [학술지(정기간행물)] - Min-Oo G / 2007 / Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus / J Exp Med 204 : 511 ~ 524
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UCI(KEPA) : I410-ECN-0101-2014-510-002511257