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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.2
- 수록면
- 89 - 93 (5page)
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초록· 키워드
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Neodiplostomum seoulense (Digenea: Neodiplostomidae) is an intestinal trematode that can cause severe mucosal pathology in the small intestines of mice and even mortality of the infected mice within 28 days after infection. We observed neuronal growth associated protein-43 (GAP-43) expression in the myenteric plexus of the small intestinal wall of N. seoulense-infected mice until day 35 post-infection (PI). BALB/c mice were infected with 200 or 500 N. seoulense metacercariae isolated from naturally infected snakes and were killed every 7 days for immunohistochemical demonstration of GAP-43 in the small intestines. N. seoulense-infected mice showed remarkable dilatation of intestinal loops compared with control mice through days 7-28 PI. Conversely, GAP-43 expression in the mucosal myenteric plexus was markedly (P<0.05) reduced in the small intestines of N. seoulense-infected mice during days 7-28 PI and was slightly normalized at day 35 PI. From this study, it is evident that neuronal damage occurs in the intestinal mucosa of N. seoulense-infected mice. However, the correlation between intestinal pathology, including the loop dilatation, and depressed GAP-43 expression remains to be elucidated.
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참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Kühn R / 1993 / Interleukin-10-deficient mice develop chronic enterocolitis / Cell 75 : 263 ~ 274
2. [학술지(정기간행물)] - Stead RH / 1991 / Remodeling of B-50 (GAP-43)- and NSE-immunoreactive mucosal nerves in the intestines of rats infected with Nippostrongylus brasiliensis / J Neurosci 11 : 3809 ~ 3821
4. [학술지(정기간행물)] - Kook J / 1998 / Pathogenicity and lethality of a minute intestinal fluke, Neodiplostomum seoulense, to various strains of mice / J Parasitol 84 : 1178 ~ 1183
5. [학술지(정기간행물)] - Chai JY / 2000 / Genetic difference in susceptibility and fatality of three strains of mice experimentally infected with Neodiplostomum seoulense / J Parasitol 86 : 1140 ~ 1144
6. [학술지(정기간행물)] - Chai JY / 1998 / Intestinal mastocytosis and goblet cell hyperplasia in BALB/c and C3H mice infected with Neodiplostomum seoulense / Korean J Parasitol 36 : 109 ~ 119
2. [학술지(정기간행물)] - Stead RH / 1991 / Remodeling of B-50 (GAP-43)- and NSE-immunoreactive mucosal nerves in the intestines of rats infected with Nippostrongylus brasiliensis / J Neurosci 11 : 3809 ~ 3821
4. [학술지(정기간행물)] - Kook J / 1998 / Pathogenicity and lethality of a minute intestinal fluke, Neodiplostomum seoulense, to various strains of mice / J Parasitol 84 : 1178 ~ 1183
5. [학술지(정기간행물)] - Chai JY / 2000 / Genetic difference in susceptibility and fatality of three strains of mice experimentally infected with Neodiplostomum seoulense / J Parasitol 86 : 1140 ~ 1144
6. [학술지(정기간행물)] - Chai JY / 1998 / Intestinal mastocytosis and goblet cell hyperplasia in BALB/c and C3H mice infected with Neodiplostomum seoulense / Korean J Parasitol 36 : 109 ~ 119
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UCI(KEPA) : I410-ECN-0101-2014-510-002511106