지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.12
- 수록면
- 301 - 308 (8page)
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초록· 키워드
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In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 post-infection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Marcos LA / 2008 / Update on hepatobiliary flukes: Fascioliasis, opisthorchiasis and clonorchiasis / Curr Opin Infect Dis 21 : 523 ~ 530
2. [학술지(정기간행물)] - Curtale F / 2007 / Human fascioliasis infection: gender differences within school-age children from endemic areas of the Nile Delta, Egypt / Trans R Soc Trop Med Hyg 101 : 155 ~ 160
3. [학술지(정기간행물)] - Rokni MB / 2008 / The present status of human helminthic diseases in Iran / Ann Trop Med Parasitol 102 : 283 ~ 295
4. [학술지(정기간행물)] - Tliba O / 2000 / Local hepatic immune response in rats during primary infection with Fasciola hepatica / Parasite 7 : 9 ~ 18
5. [학술지(정기간행물)] - Molina EC / 2005 / Cellular and humoral responses in liver of cattle and buffaloes infected with a single dose of Fasciola gigantica / Vet Parasitol 131 : 157 ~ 163
2. [학술지(정기간행물)] - Curtale F / 2007 / Human fascioliasis infection: gender differences within school-age children from endemic areas of the Nile Delta, Egypt / Trans R Soc Trop Med Hyg 101 : 155 ~ 160
3. [학술지(정기간행물)] - Rokni MB / 2008 / The present status of human helminthic diseases in Iran / Ann Trop Med Parasitol 102 : 283 ~ 295
4. [학술지(정기간행물)] - Tliba O / 2000 / Local hepatic immune response in rats during primary infection with Fasciola hepatica / Parasite 7 : 9 ~ 18
5. [학술지(정기간행물)] - Molina EC / 2005 / Cellular and humoral responses in liver of cattle and buffaloes infected with a single dose of Fasciola gigantica / Vet Parasitol 131 : 157 ~ 163
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UCI(KEPA) : I410-ECN-0101-2014-510-002534774