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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.4
- 수록면
- 255 - 258 (4page)
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초록· 키워드
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Spillage of cyst contents during surgical operation is the major cause of recurrence after hydatid cyst surgery. Instillation of a scolicidal agent into a hepatic hydatid cyst is the most commonly employed measure to prevent this complication. SB202190 is a pyridinyl imidazole derivative and is known to be a specific inhibitor of p38 MAPK. In the present study, the scolicidal effect of SB202190 was investigated. Freshly isolated Echinococcus granulosus protoscolices were subjected to SB202190 treatment (10, 20, 40, and 80 μM), and the effects on parasite viability were monitored by trypan blue staining. Corresponding effects were visualized by scanning and transmission electron microscopy. Dose-dependent protoscolex death within a few days of SB202190 treatment was observed. Although the in vitro scolicidal effect of SB202190 was satisfactory, the in vivo efficacy of this drug and also possible side effects remain to be further investigated.
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참고문헌 (13)
참고문헌 신청
1. [학술지(정기간행물)] - McManus DP / 2003 / Echinococcosis / Lancet 362 : 1295 ~ 1304
2. [학술지(정기간행물)] - Moro P / 2009 / Echinococcosis: a review / Int J Infect Dis 13 : 125 ~ 133
3. [학술지(정기간행물)] - Tozar E / 2005 / The effects of cetrimide-chlorhexidine combination on the hepatopancreatico- biliary system / World J Surg 29 : 754 ~ 758
4. [학술지(정기간행물)] - Topcu O / 2009 / Efficacy of chlorhexidine gluconate during surgery for hydatid cyst / World J Surg 33 : 1274 ~ 1280
5. [학술지(정기간행물)] - Moazeni M / 2010 / In vitro effectiveness of acidic and alkline solutions on scolices of hydatid cyst / Parasitol Res 106 : 853 ~ 856
2. [학술지(정기간행물)] - Moro P / 2009 / Echinococcosis: a review / Int J Infect Dis 13 : 125 ~ 133
3. [학술지(정기간행물)] - Tozar E / 2005 / The effects of cetrimide-chlorhexidine combination on the hepatopancreatico- biliary system / World J Surg 29 : 754 ~ 758
4. [학술지(정기간행물)] - Topcu O / 2009 / Efficacy of chlorhexidine gluconate during surgery for hydatid cyst / World J Surg 33 : 1274 ~ 1280
5. [학술지(정기간행물)] - Moazeni M / 2010 / In vitro effectiveness of acidic and alkline solutions on scolices of hydatid cyst / Parasitol Res 106 : 853 ~ 856
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UCI(KEPA) : I410-ECN-0101-2014-510-002535599