Different Clinical Outcomes of Entamoeba histolytica in Malaysia: Does Genetic Diversity Exist?

Tengku Shahrul Anuar; Hesham M. Al-Mekhlafi; Mohamed Kamel Abdul Ghani; Siti Nor Azreen; Fatmah Md Salleh; Nuraffini Ghazali; Mekadina Bernadus; Norhayati Moktar

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자료유형: 학술저널

저자정보: Tengku Shahrul Anuar (Universiti Kebangsaan Malaysia) Hesham M. Al-Mekhlafi (University of Malaya) Mohamed Kamel Abdul Ghani (Universiti Kebangsaan Malaysia) Siti Nor Azreen (Universiti Kebangsaan Malaysia) Fatmah Md Salleh (Universiti Kebangsaan Malaysia) Nuraffini Ghazali (Universiti Kebangsaan Malaysia) Mekadina Bernadus (Universiti Kebangsaan Malaysia) Norhayati Moktar (Universiti Kebangsaan Malaysia)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.51 No.2

발행연도: 2013.4

수록면: 231 - 236 (6page)

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The present study was conducted to investigate the clinical outcomes of Entamoeba histolytica infection in symptomatic and asymptomatic Orang Asli (aborigine) communities in Malaysia. Examination was performed on 500 stool samples obtained from Orang Asli communities in 3 different states using formalin-ether concentration, trichrome staining, and single-round PCR techniques. Out of 500 stool samples, single infection of E. histolytica, Entamoeba dispar, and Entamoeba moshkovskii was identified in 3.2%, 13.4%, and 1%, respectively. In addition, 10 samples had mixed infections with E. histolytica and E. dispar. Six samples containing E. dispar were also positive for E. moshkovskii, and only 2 samples had E. histolytica in association with E. dispar and E. moshkovskii. Seventeen E. histolytica-positive samples were from symptomatic subjects, whereas the remaining 11 samples came from asymptomatic subjects. These findings suggest a predominant distribution of pathogenic potential of E. histolytica strains in this community. Therefore, further studies on genotyping of E. histolytica is required, to find out association between E. histolytica genotype and the outcome of the infection.

#Entamoeba histolytica #symptomatic #asymptomatic #clinical outcome #genetic diversity #Malaysia

참고문헌 (19)

참고문헌 신청

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