지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study aimed to evaluate the effects of root of Curcumin longa (RCL) on LPS-induced COPD (chronic obstructive pulmonary disease) model.
Materials and Methods: Extract of RCL was treated to RAW 264.7 cells and LPS-induced COPD mouse model. Then, various parameters such as cell-based protective activity, airflow limitation, accumulation of immune cells and histopathological finding were analyzed.
Results: RCL showed a protective effect on LPS-induced cytotoxicity in RAW 264.7 cells. RCL treatment also revealed a protective effect on LPS-induced lung injury in a COPD mouse model. This effect was demonstrated via the reduction of accumulation of immune cells and pathophysiological regulation of caspase 3, elastin and collagen in lung tissue.
Conclusions: These data suggest that RCL has a pharmaceutical property on lung injury. This study provides scientific evidence for the efficacy of RCL for clinical application to COPD patients.
Materials and Methods: Extract of RCL was treated to RAW 264.7 cells and LPS-induced COPD mouse model. Then, various parameters such as cell-based protective activity, airflow limitation, accumulation of immune cells and histopathological finding were analyzed.
Results: RCL showed a protective effect on LPS-induced cytotoxicity in RAW 264.7 cells. RCL treatment also revealed a protective effect on LPS-induced lung injury in a COPD mouse model. This effect was demonstrated via the reduction of accumulation of immune cells and pathophysiological regulation of caspase 3, elastin and collagen in lung tissue.
Conclusions: These data suggest that RCL has a pharmaceutical property on lung injury. This study provides scientific evidence for the efficacy of RCL for clinical application to COPD patients.
목차
서론
연구재료와 방법
결과
고찰
결론
참고문헌
참고문헌 (53)
참고문헌 신청
1. [학술지(정기간행물)] - Hurd S / 2000 / The impact of COPD on lung health worldwide: epidemiology and incidence / Chest 117 (2) : 1S ~ 4
2. [학술지(정기간행물)] - Mannino DM / 2002 / COPD: epidemiology, prevalence, morbidity and mortality, and disease heteroge neity / Chest 121 : 121S ~ 126S
3. [학술지(정기간행물)] - Doll R / 2004 / Mortality in relation to smoking: 50 years’observations on male British doctors / BMJ 328 : 1519 ~
4. [학술지(정기간행물)] - Mannino DM / 2007 / The epidemiology and economics of chronic obstructive pulmonary disease / Proc Am Thorac Soc 4 (7) : 502 ~ 506
5. [학술지(정기간행물)] - 유철규 / 2009 / 만성폐쇄성폐질환의 병인과 병태생리 / 대한내과학회지 77 (4) : 383 ~ 400
2. [학술지(정기간행물)] - Mannino DM / 2002 / COPD: epidemiology, prevalence, morbidity and mortality, and disease heteroge neity / Chest 121 : 121S ~ 126S
3. [학술지(정기간행물)] - Doll R / 2004 / Mortality in relation to smoking: 50 years’observations on male British doctors / BMJ 328 : 1519 ~
4. [학술지(정기간행물)] - Mannino DM / 2007 / The epidemiology and economics of chronic obstructive pulmonary disease / Proc Am Thorac Soc 4 (7) : 502 ~ 506
5. [학술지(정기간행물)] - 유철규 / 2009 / 만성폐쇄성폐질환의 병인과 병태생리 / 대한내과학회지 77 (4) : 383 ~ 400
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UCI(KEPA) : I410-ECN-0101-2014-510-003642417